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NCT03497884

Individualized Precise Localization of rTMS on Primary Motor Area

Completed NA Last updated 30 May 2018
What this trial tests

NA trial testing rTMS in Parkinson Disease in 38 participants. Completed in 15 April 2018.

Timeline
4 September 2017
Primary endpoint
15 April 2018
15 April 2018

Quick facts

Lead sponsorHangzhou Normal University
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingsingle
Primary purposetreatment
Enrollment38
Start date4 September 2017
Primary completion15 April 2018
Estimated completion15 April 2018
Sites2 locations across China

Drugs / interventions tested

Conditions studied

Sponsor

Hangzhou Normal University

Who can join

Adults 19 to 30, any sex, with Parkinson Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Parkinson's disease (PD) patients have some problem with self-initiated movement task. Compared with health controls, task meta-analysis found that PD patients showed abnormal activation in pre-supplementary motor area (pre-SMA) and putamen. And the functional connectivity has already been reported between pre-SMA and putamen in 2013. Repetitive Transcranial Magnetic Stimulation (rTMS) is a sage and painless technique to activate cortical areas. The deep brain structure can be activated via stimulating superficial cortex by rTMS. For investigating the mechanism of self-initiated movement, this project is using functional magnetic resonance imaging (fMRI) to individualize the precise localization in motor area and combining rTMS to activate putamen.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Low-frequency rTMS targeting individual self-initiated finger-tapping task activation modulates the amplitude of local neural activity in the putamen.
    Wang J, Deng XP, Hu YS, Yue J, et al · · 2023 · cited 7× · PMID 36562546 · DOI 10.1002/hbm.26045

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Other trials of rTMS

Trials testing the same drug.

Other recruiting trials for Parkinson Disease

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Other Hangzhou Normal University trials

Trials by the same sponsor.

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