Last reviewed · How we verify
NCT03497611: Conduct
Edwards SAPIEN 3 PPI Registry
trial testing transcatheter valve implantation in Aortic Valve Stenosis in 1,000 participants. Completed in 3 March 2019.
3 November 2018
Quick facts
| Lead sponsor | Institut für Pharmakologie und Präventive Medizin |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 1,000 |
| Start date | 30 April 2018 |
| Primary completion | 3 November 2018 |
| Estimated completion | 3 March 2019 |
| Sites | 4 locations across Germany |
Drugs / interventions tested
- transcatheter valve implantation
Conditions studied
- Aortic Valve Stenosis — all drugs for Aortic Valve Stenosis →
- AV Block — all drugs for AV Block →
- Bundle-Branch Block — all drugs for Bundle-Branch Block →
Sponsor
Institut für Pharmakologie und Präventive Medizin — full company profile →
Who can join
Eligibility, any sex, with Aortic Valve Stenosis or AV Block. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
There are patient related risk factors for PPI that can be identified and assessed in retrospective pooling of 1000+ TAVI patient datasets. Retrospective pooling of 6 datasets already available at participating centres (4 sites in Germany, 1 in Zwolle / The Netherlands, 1 in Linköping / Sweden). Additional assessment of calcifications using a CT data core lab. Statistical analysis of the obtained dataset with respect to the objectives of the registry.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Modifiable risk factors for permanent pacemaker after transcatheter aortic valve implantation: CONDUCT registry.
Rudolph T, Droppa M, Baan J, Nielsen NE, et al · · 2023 · cited 10× · PMID 36750275 · DOI 10.1136/openhrt-2022-002191 -
Risk factors for permanent pacemaker implantation in patients receiving a balloon-expandable transcatheter aortic valve prosthesis.
Droppa M, Rudolph TK, Baan J, Nielsen NE, et al · · 2020 · cited 7× · PMID 32591894 · DOI 10.1007/s00380-020-01653-6 -
One-year Outcomes of Permanent Pacemaker Implantation after Transcatheter Aortic Valve Replacement: CONDUCT Registry: A Propensity Score-Matched Comparison.
Droppa M, Geisler T, Baan J, Nielsen NE, et al · · 2025 · PMID 40607011 · DOI 10.15420/aer.2024.52
Verify or expand the search:
- PubMed search for NCT03497611
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of transcatheter valve implantation
Trials testing the same drug.
- NCT03715894 — Prospective Arm of Conduct - Edwards SAPIEN3 PPI Registry · completed
Other recruiting trials for Aortic Valve Stenosis
Currently open trials in the same condition.
- NCT07455292 — Phenotyping Left Ventricle Failure With Hemodynamic Biomarkers From 4D Flow Magnetic Resonance Imaging · NA · recruiting
- NCT07008911 — CardioHeartConnect: Commercially Available Fitness for Cardiac Rehabilitation · NA · recruiting
- NCT07145463 — Prospective, Multicenter, Randomized Controlled Clinical Study Evaluating the VitaFlow Liberty® Flex Transcatheter Aorti · NA · recruiting
- NCT07520656 — Impact of Transcatheter Aortic Valve Implantation and Mitral Valve Repair on Sleep-Disordered Breathing · recruiting
- NCT07267117 — Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease · recruiting
Other Institut für Pharmakologie und Präventive Medizin trials
Trials by the same sponsor.
- NCT06953206 — Prospective, Long-term Evaluation of the SAPIEN 3 Ultra RESILIA Valve · not yet recruiting
- NCT06702527 — Optimizing Clinical Outcomes in Patients Undergoing Mitral Transcatheter Edge-to-edge Repair (M-TEER) for Severe Functio · not yet recruiting
- NCT05750173 — The EASE-IT CT Registry · completed
- NCT04804748 — The DefiPace Study · recruiting
- NCT04579445 — Setting a Benchmark for Resource Utilization and Quality of Care in Patients Undergoing TAVI in Europe · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03497611 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Institut für Pharmakologie und Präventive Medizin
- Last refreshed: 4 September 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03497611.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing