NCT03494387 (VIXIE) is a Phase 4 clinical trial of Oxygen in Postoperative Cardiac Complication, sponsored by University Hospital Bispebjerg and Frederiksberg.

Who is sponsoring NCT03494387?

NCT03494387 is sponsored by University Hospital Bispebjerg and Frederiksberg.

What drugs are being tested in NCT03494387?

Interventions in NCT03494387: Oxygen, Antioxidants.

What condition does NCT03494387 study?

NCT03494387 studies Postoperative Cardiac Complication.

Is NCT03494387 still recruiting?

NCT03494387 is currently completed. Last updated 30 April 2021.

Last reviewed 2021-04-30 · How we verify

NCT03494387: VIXIE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

VitamIn and oXygen Interventions and Cardiovascular Events

Completed Phase 4 Last updated 30 April 2021

What this trial tests

Phase 4 trial testing Oxygen in Postoperative Cardiac Complication in 600 participants. Completed in 24 March 2020.

Timeline

6 April 2018

Primary endpoint
1 March 2020

24 March 2020

Quick facts

Lead sponsor	University Hospital Bispebjerg and Frederiksberg
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	factorial
Masking	double
Primary purpose	prevention
Enrollment	600
Start date	6 April 2018
Primary completion	1 March 2020
Estimated completion	24 March 2020
Sites	4 locations across Denmark

Drugs / interventions tested

Oxygen — full drug profile →
Antioxidants — full drug profile →

Conditions studied

Postoperative Cardiac Complication — all drugs for Postoperative Cardiac Complication →

Sponsor

University Hospital Bispebjerg and Frederiksberg

Who can join

45 and older, any sex, with Postoperative Cardiac Complication. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study examines the risks and benefits of antioxidants and normal versus high inspiratory oxygen fraction during anaesthesia.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Effects of Hyperoxia and Antioxidants on Mortality, Hospital Admissions, and Myocardial Infarction After Noncardiac Surgery: 1-Year Follow-Up of a Randomized Controlled Trial.
Loft FC, Holse C, Aasvang EK, Vester-Andersen M, et al · · 2025 · cited 2× · PMID 41055553 · DOI 10.1111/aas.70118
Equity of participants in clinical trials in critical care and perioperative medicine research: a systematic review.
Wong JKL, Thomas C, Gravett H, Thobhani K, et al · · 2025 · cited 1× · PMID 40746650 · DOI 10.1016/j.bjao.2025.100425

Verify or expand the search:

Other trials of Oxygen

Trials testing the same drug.

NCT06327373 — A Feasibility Study of Supplemental Oxygen to Improve Pulmonary Hypertension in People With Intradialytic Hypoxemia · Phase 1, PHASE2 · not yet recruiting
NCT07464730 — Postoperative High-flow Nasal Oxygenation After High-risk Surgery in the Frail Adult · NA · not yet recruiting
NCT06498908 — Intracervical Balloon Placement With Nitrous Oxide Administration · Phase 3 · withdrawn
NCT07245628 — A Trial of Self-Adjusted Nitrous Versus Placebo During Office Vasectomy · EARLY_PHASE1 · recruiting
NCT07369232 — Cerebral Hemodynamic Effects of Oxygen and Antioxidants (CHEOXANT) · NA · recruiting

Other University Hospital Bispebjerg and Frederiksberg trials

Trials by the same sponsor.

NCT07060586 — The Effect of Sphenopalatine Ganglion Block on Headache and Vasalgia · NA · completed
NCT06911411 — PALLIATIVE ASSESSMENT COHORT IN THE GERIATRIC EMERGENCY SETTING · not yet recruiting
NCT06405750 — Left Atrial Appendage Arrhythmogenic and Thrombogenic Substrate · NA · recruiting
NCT06532825 — Cardiac Autonomic Dysfunction As a Sign of Irreversible Advanced Heart Failure · recruiting
NCT06184581 — Lithium Versus Lamotrigine in Bipolar Disorder, Type II · Phase 4 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03494387 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital Bispebjerg and Frederiksberg
Last refreshed: 30 April 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03494387.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing