NCT03494114 is a Phase 1 clinical trial of Ga-EC2115 in COPD, sponsored by Vanderbilt University Medical Center.

Who is sponsoring NCT03494114?

NCT03494114 is sponsored by Vanderbilt University Medical Center.

What drugs are being tested in NCT03494114?

Interventions in NCT03494114: Ga-EC2115.

Is NCT03494114 still recruiting?

NCT03494114 is currently terminated. Last updated 11 August 2021.

Last reviewed 2021-08-11 · How we verify

NCT03494114

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Imaging Activated Macrophages in the Lungs

Terminated Phase 1 Last updated 11 August 2021

What this trial tests

Phase 1 trial testing Ga-EC2115 in COPD in 13 participants. Terminated before completion.

Timeline

29 November 2018

Primary endpoint
20 November 2019

13 January 2021

Quick facts

Lead sponsor	Vanderbilt University Medical Center
Phase	Phase 1
Status	Terminated
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	single
Primary purpose	diagnostic
Enrollment	13
Start date	29 November 2018
Primary completion	20 November 2019
Estimated completion	13 January 2021
Sites	1 location across United States

Drugs / interventions tested

Ga-EC2115 — full drug profile →

Conditions studied

COPD — all drugs for COPD →

Sponsor

Vanderbilt University Medical Center

Who can join

45 and older, any sex, with COPD. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To test whether folate-based positron emission tomography (PET) imaging using 68Ga-EC2115 can differentiate chronic obstructive pulmonary disease (COPD) patients from control subjects and determine whether the PET signal correlates with measurements of inflammation and disease severity.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

The yin and yang of imaging tumor associated macrophages with PET and MRI.
Mukherjee S, Sonanini D, Maurer A, Daldrup-Link HE. · · 2019 · cited 54× · PMID 31695797 · DOI 10.7150/thno.37306
Radiation dosimetry of <sup>18</sup>F-AzaFol: A first in-human use of a folate receptor PET tracer.
Gnesin S, Müller J, Burger IA, Meisel A, et al · · 2020 · cited 28× · PMID 32270313 · DOI 10.1186/s13550-020-00624-2

Verify or expand the search:

Other recruiting trials for COPD

Currently open trials in the same condition.

NCT07344649 — Turkish Validation of the Nijmegen Questionnaire in COPD · recruiting
NCT07524023 — Emotional-distress-based Integrated Care Programme in Patients With Stable COPD · NA · recruiting
NCT07460154 — Structured Review: To Optimise Management and Prevent Harm in COPD · NA · recruiting
NCT07462221 — Effect of Telenursing on Oral Health · NA · recruiting
NCT07051707 — Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD · NA · recruiting

Other Vanderbilt University Medical Center trials

Trials by the same sponsor.

NCT07005037 — Swallowing Impairments in ICU Survivors and Community-Dwelling Adults · not yet recruiting
NCT07527273 — Cognitive Enhancement in Recurrent Depression (The COG-D-R Study) · NA · not yet recruiting
NCT07295288 — Botox Injections in Non-Cranial Nerve VII Innervated Muscles for Facial Synkinesis · Phase 4 · not yet recruiting
NCT07431541 — Topical Carboxytherapy Paste Following Microneedling · Phase 1, PHASE2 · not yet recruiting
NCT07224711 — The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery · Phase 4 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03494114 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Vanderbilt University Medical Center
Last refreshed: 11 August 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03494114.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing