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NCT03493035: MCAA
Risk Factors of Middle Cerebral Artery Aneurysm.
trial testing Computed tomography angiography (3D CTA) in Middle Cerebral Artery Aneurysm in 190 participants. Completed in 15 June 2017.
15 June 2017
Quick facts
| Lead sponsor | Medical University of Silesia |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 190 |
| Start date | 16 June 2015 |
| Primary completion | 15 June 2017 |
| Estimated completion | 15 June 2017 |
| Sites | 1 location across Poland |
Drugs / interventions tested
- Computed tomography angiography (3D CTA)
- Transcranial color-coded sonography (TCCS)
Conditions studied
- Middle Cerebral Artery Aneurysm — all drugs for Middle Cerebral Artery Aneurysm →
Sponsor
Medical University of Silesia
Who can join
Adults 18 to 75, any sex, with Middle Cerebral Artery Aneurysm. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
According to the current view, cerebral aneurysms are acquired degenerative lesions resulting from hemodynamic stress. This single-center case-control study will be carried out at the Department of Neurosurgery, Regional Hospital in Sosnowiec, Medical University of Silesia in Katowice, Poland between June 2015 and June 2017. The aim of the study is to determine morphometric and hemodynamic parameters of aneurysmal and non-aneurysmal middle cerebral artery (MCA) bifurcations and to analyze their relationship with aneurysm formation. A minimum of 75 cases and 75 age- and sex-matched controls will be required for the study. Characteristics of the MCA bifurcations will be determined with computed tomography angiography (CTA) and transcranial color-coded sonography (TCCS). The following variables will be evaluated as potential risk factors for MCA aneurysm formation: radii and cross-sectional area of the main MCA trunk and its branches, tortuosity of MCA trunk, asymmetry ratio, area ratio, the angle between the post-bifurcation branches, the angles between the MCA trunk and the larger and smaller branch, volume flow rate, mean flow velocity and pulsatility index of the MCA. All morphometric and hemodynamic parameters will be assessed as potential risk factors for MCA aneurysm formation.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Morphological and Hemodynamic Risk Factors for Middle Cerebral Artery Aneurysm: a Case-Control Study of 190 Patients.
Kaspera W, Ćmiel-Smorzyk K, Wolański W, Kawlewska E, et al · · 2020 · cited 16× · PMID 32029748 · DOI 10.1038/s41598-019-56061-2
Verify or expand the search:
- PubMed search for NCT03493035
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03493035 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Medical University of Silesia
- Last refreshed: 18 February 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03493035.
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