Drinkers' Intervention to Prevent Tuberculosis (DIPT Study)

NCT03492216 NA COMPLETED Results posted

There is an urgent global need to decrease the high mortality of tuberculosis (TB) in persons with HIV as TB is the leading cause of death among persons with HIV worldwide. The DIPT (Drinkers' Intervention to Prevent TB) study is a randomized, 2x2 factorial trial among HIV/TB co-infected adults in Uganda with heavy alcohol use (n=680 persons, 340 each U01). The goal of the study is to determine whether economic incentive interventions can promote both reduced alcohol use and isoniazid (INH) pill taking among HIV/TB co-infected adult heavy drinkers, during isoniazid preventive therapy (IPT: a six-month course of INH) at HIV clinics in southwestern Uganda. Participants will be randomized to one of four arms: Arm 1: no incentives (control); Arm 2: economic incentives for decreasing alcohol use only; Arm 3: economic incentives for IPT adherence only; Arm 4: economic incentives for decreasing alcohol use and for IPT adherence (rewarded independently).

Details

Lead sponsor	University of California, San Francisco
Phase	NA
Status	COMPLETED
Enrolment	680
Start date	Mon Apr 16 2018 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Tue Aug 02 2022 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• HIV/AIDS
• Tuberculosis

Interventions

• Incentives for negative EtG test
• Incentives for positive IsoScreen test

Countries

Uganda