NCT03490448

The Changes of Body Composition, Glucolipid Metabolism and Bone Metabolism in Obese Children After Weight Loss

Completed NA Last updated 6 April 2018

What this trial tests

NA trial testing aerobic exercise and appropriate caloric control in Obesity, Childhood in 53 participants. Completed in 16 August 2014.

Timeline

6 July 2014

Primary endpoint
16 August 2014

16 August 2014

Quick facts

Lead sponsor	Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	health services research
Enrollment	53
Start date	6 July 2014
Primary completion	16 August 2014
Estimated completion	16 August 2014
Sites	1 location across China

Drugs / interventions tested

• aerobic exercise and appropriate caloric control

Conditions studied

• Obesity, Childhood — all drugs for Obesity, Childhood →
• Vitamin D Deficiency — all drugs for Vitamin D Deficiency →

Sponsor

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Who can join

Adults 9 to 17, any sex, with Obesity, Childhood or Vitamin D Deficiency. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Vitamin D plays a significant role in calcium and phosphorus homeostasis for maintaining structural integrity and function of musculoskeletal system. Furthermore, recent studies have revealed that vitamin D can decrease the risk of many conditions other than skeletal disease, including autoimmune diseases, cancers, obesity and obesity-related diseases, such as type 2 diabetes and cardiovascular disease. Vitamin D may influence calcium absorption to affect obesity indirectly, regulate adipocyte differentiation and relieve the development of metabolic syndrome by mediating levels of inflammatory factors.

Another indicator of bone metabolism-osteocalcin may also be involved in energy metabolism and glucose metabolism, and undercarboxylated osteocalcin (ucOC) is the form which has physiological activity. ucOC may recombine with the receptors on the surface of pancreas β cells, adipocytes, hepatocytes and intestinal endocrine cell to regulate insulin secretion and insulin sensitivity.

Currently, the prevalence of vitamin D deficiency is a global problem in all age groups currently, even in countries with sun exposure all year around. The obesity group tend to have a higher incidence of vitamin D deficiency.Moreover, the obesity group tend to have a higher incidence of vitamin D deficiency and a lower level of serum osteocalcin.

This study observed the changes of body composition and glucolipid metabolism and bone metabolism during weight loss, and investigated the correlations among them.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Uric acid is associated with adiposity factors, especially with fat mass reduction during weight loss in obese children and adolescents.
   Niu Y, Zhao XL, Ruan HJ, Mao XM, et al · · 2020 · cited 10× · PMID 32983243 · DOI 10.1186/s12986-020-00500-9