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NCT03483493: ORBIT
Online Remote Behavioural Intervention for Tics (ORBIT)
NA trial testing Exposure Response Prevention for tics in Tic Disorders in 224 participants. Completed in 12 April 2021.
18 February 2020
Quick facts
| Lead sponsor | Nottinghamshire Healthcare NHS Trust |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 224 |
| Start date | 7 May 2018 |
| Primary completion | 18 February 2020 |
| Estimated completion | 12 April 2021 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Exposure Response Prevention for tics
- Psychoeducation for tics
Conditions studied
- Tic Disorders — all drugs for Tic Disorders →
- Tourette Syndrome — all drugs for Tourette Syndrome →
Sponsor
Nottinghamshire Healthcare NHS Trust
Who can join
Adults 9 to 17, any sex, with Tic Disorders or Tourette Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Online Remote Behavioural Intervention for Tics (ORBIT). Primary objective: to evaluate the clinical effectiveness of BiP Tic, a therapist-guided, parent-assisted, internet-based behavioural therapy intervention for tics in young people, compared with usual care plus online education. Secondary objectives include 1) optimising the design of the intervention, 2) undertaking an internal pilot, 3) evaluating cost effectiveness and 4) longer term impact, and 5) identifying barriers to implementation.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
Therapist-supported online remote behavioural intervention for tics in children and adolescents in England (ORBIT): a multicentre, parallel group, single-blind, randomised controlled trial.
Hollis C, Hall CL, Jones R, Marston L, et al · · 2021 · cited 53× · PMID 34480868 · DOI 10.1016/s2215-0366(21)00235-2 -
Investigating a therapist-guided, parent-assisted remote digital behavioural intervention for tics in children and adolescents-'Online Remote Behavioural Intervention for Tics' (ORBIT) trial: protocol of an internal pilot study and single-blind randomised controlled trial.
Hall CL, Davies EB, Andrén P, Murphy T, et al · · 2019 · cited 37× · PMID 30610027 · DOI 10.1136/bmjopen-2018-027583 -
Opportunities and challenges of delivering digital clinical trials: lessons learned from a randomised controlled trial of an online behavioural intervention for children and young people.
Hall CL, Sanderson C, Brown BJ, Andrén P, et al · · 2020 · cited 25× · PMID 33298127 · DOI 10.1186/s13063-020-04902-1 -
Long-term clinical and cost-effectiveness of a therapist-supported online remote behavioural intervention for tics in children and adolescents: extended 12- and 18-month follow-up of a single-blind randomised controlled trial.
Hollis C, Hall CL, Khan K, Jones R, et al · · 2023 · cited 17× · PMID 36649686 · DOI 10.1111/jcpp.13756 -
Online remote behavioural intervention for tics in 9- to 17-year-olds: the ORBIT RCT with embedded process and economic evaluation.
Hollis C, Hall CL, Khan K, Le Novere M, et al · · 2023 · cited 12× · PMID 37924247 · DOI 10.3310/cpms3211 -
The COVID-19 pandemic and its impact on tic symptoms in children and young people: a prospective cohort study.
Hall CL, Marston L, Khan K, Brown BJ, et al · · 2023 · cited 11× · PMID 35416566 · DOI 10.1007/s10578-022-01348-1 -
Healthcare utilisation and costs associated with poor access to diagnosis and treatment for children and young people with tic disorders.
Hall CL, Le Novere M, Murphy T, McNally E, et al · · 2024 · cited 9× · PMID 39515845 · DOI 10.1136/bmjment-2024-301241 -
Protocol for the Process Evaluation of the Online Remote Behavioural Intervention for Tics (ORBIT) randomized controlled trial for children and young people.
Khan K, Hollis C, Hall CL, Davies EB, et al · · 2020 · cited 9× · PMID 31898510 · DOI 10.1186/s13063-019-3974-3
Verify or expand the search:
- PubMed search for NCT03483493
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Nottinghamshire Healthcare NHS Trust trials
Trials by the same sponsor.
- NCT03368573 — QbTest Utility for Optimising Treatment in ADHD (QUOTA) · NA · completed
- NCT02442193 — Individual Placement and Support for Patients With Offending Histories · NA · terminated
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03483493 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Nottinghamshire Healthcare NHS Trust
- Last refreshed: 9 September 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03483493.
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