NCT03482063: MAST

The Effects of 12 Weeks Supplementation With a B-vitamin and Herbal Supplement on Neurocognitive Function and Mood

Completed Phase 2 Last updated 18 March 2020

What this trial tests

Phase 2 trial testing Swisse Ultiboost Memory + Focus in Neurocognitive Function in 141 participants. Completed in 9 January 2020.

Timeline

18 June 2018

Primary endpoint
9 January 2020

9 January 2020

Quick facts

Lead sponsor	Swisse Wellness Pty Ltd
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	supportive care
Enrollment	141
Start date	18 June 2018
Primary completion	9 January 2020
Estimated completion	9 January 2020
Sites	1 location across Australia

Drugs / interventions tested

• Swisse Ultiboost Memory + Focus
• Placebo

Conditions studied

• Neurocognitive Function — all drugs for Neurocognitive Function →
• Mood — all drugs for Mood →

Sponsor

Swisse Wellness Pty Ltd

Who can join

Adults 40 to 65, any sex, with Neurocognitive Function or Mood. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of the present study is to evaluate chronic supplementation with Swisse Ultiboost Memory + Focus over a 12 week period on memory in individuals with optimal and sub-optimal nutrient profiles.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

1. Self-Selection Bias: An Essential Design Consideration for Nutrition Trials in Healthy Populations.
   Young LM, Gauci S, Scholey A, White DJ, et al · · 2020 · cited 20× · PMID 33240921 · DOI 10.3389/fnut.2020.587983
2. Self-Reported Diet Quality Differentiates Nutrient Intake, Blood Nutrient Status, Mood, and Cognition: Implications for Identifying Nutritional Neurocognitive Risk Factors in Middle Age.
   Young LM, Gauci S, Scholey A, White DJ, et al · · 2020 · cited 11× · PMID 32998296 · DOI 10.3390/nu12102964
3. Investigating the Effects of a Multinutrient Supplement on Cognition, Mood and Biochemical Markers in Middle-Aged Adults with 'Optimal' and 'Sub-Optimal' Diets: A Randomized Double Blind Placebo Controlled Trial.
   Young LM, Gauci S, Arnoldy L, Martin L, et al · · 2022 · cited 7× · PMID 36501109 · DOI 10.3390/nu14235079
4. The Association Between Diet and Cardio-Metabolic Risk on Cognitive Performance: A Cross-Sectional Study of Middle-Aged Australian Adults.
   Gauci S, Young LM, Arnoldy L, Scholey A, et al · · 2022 · cited 7× · PMID 35571882 · DOI 10.3389/fnut.2022.862475
5. Towards consistency in dietary pattern scoring: standardising scoring workflows for healthy dietary patterns using 24-h recall and two variations of a food frequency questionnair.
   Arnoldy L, Gauci S, Lassemillante AM, Verster JC, et al · · 2024 · cited 6× · PMID 38225925 · DOI 10.1017/s0007114524000072
6. Assessing the association between the Mediterranean, Dietary Approaches to Stop Hypertension and Mediterranean-DASH Intervention for Neurodegenerative Delay dietary patterns, structural connectivity and cognitive function.
   Arnoldy L, Gauci S, Young LM, Macpherson H, et al · · 2025 · cited 2× · PMID 40017312 · DOI 10.1017/s0007114525000406