Last reviewed · How we verify
NCT03481751
Validation and Interobserver Reliability of a Simple Ultrasound Score for Crohn's Disease
trial testing Diagnostic test: Ultrasound in Crohn Disease in 124 participants. Status unknown.
20 December 2020
Quick facts
| Lead sponsor | Haukeland University Hospital |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 124 |
| Start date | 8 January 2018 |
| Primary completion | 20 December 2020 |
| Estimated completion | 20 December 2022 |
| Sites | 3 locations across Norway |
Drugs / interventions tested
- Diagnostic test: Ultrasound
Conditions studied
- Crohn Disease — all drugs for Crohn Disease →
- Ultrasound — all drugs for Ultrasound →
Sponsor
Haukeland University Hospital
Who can join
Adults 18 to 75, any sex, with Crohn Disease or Ultrasound. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Crohn's disease (CD) is a chronic inflammatory disease in the gastrointestinal (GI) tract. It is characterized by an alternating course between remission and relapse, which necessitates subsequent adjustments in medical therapy. Thus, it is important to have suitable tools to assess disease activity, and currently the reference standard is using ileocolonoscopy. However, ileocolonoscopy causes major patient discomfort and due to logistic reasons, it cannot be performed on a regular basis. High frequency ultrasound (US) is a potentially useful tool to evaluate changes in disease activity in affected bowel segments. Although there are some studies using US in CD patients to construct ultrasonographic scoring systems, there are no validated scores in daily clinical practice. In a recent study by Nylund et al, we used multiple linear regression to select which simple conventional ultrasound parameters that should be included in an ultrasound scoring system (Simple Ultrasound Score of Crohn's Disease (SUS-CD)) using endoscopy as a reference (unpublished data). In this study, we aim to validate this scoring system using an endoscopic score (Simple endoscopic activity score for Crohn's disease (SES-CD)) as reference standard and to assess interobserver variability. The scoring system might be a useful supplement to endoscopy to follow up CD patients.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Development and Validation of a Simple Ultrasound Activity Score for Crohn's Disease.
Sævik F, Eriksen R, Eide GE, Gilja OH, et al · · 2021 · cited 86× · PMID 32504533 · DOI 10.1093/ecco-jcc/jjaa112 -
Integrating Intestinal Ultrasound to Clinical Trials in Patients With Crohn's Disease: Opportunities and Challenges.
Jairath V, Adsul S, Allocca M, Danese S, et al · · 2025 · cited 2× · PMID 40971817 · DOI 10.1093/ibd/izaf196
Verify or expand the search:
- PubMed search for NCT03481751
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Crohn Disease
Currently open trials in the same condition.
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- NCT07310095 — A Study to Evaluate the Efficacy of Guselkumab in Chinese Participants With Crohn's Disease (CD) · Phase 4 · recruiting
- NCT07364734 — Epidemiological Characteristics and Efficacy Evaluation of Difficult-To-Treat Crohn's Disease · recruiting
- NCT07170462 — Cranberry and Gut Health in Crohn's Disease · EARLY_PHASE1 · recruiting
- NCT07196722 — A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease · Phase 2, PHASE3 · recruiting
Other Haukeland University Hospital trials
Trials by the same sponsor.
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- NCT07392697 — The Intravenous Amino Acid Therapy for Vascular Rigidity in End Stage Renal Disease · NA · not yet recruiting
- NCT07304219 — Physical Activity Based Treatment for Youth With Depression and Anxiety · NA · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03481751 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Haukeland University Hospital
- Last refreshed: 4 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03481751.
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