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NCT03481205: ICARUS
Ischemic Conditioning During Air tRansport Save penUmbral Tissue
NA trial testing Ischemic conditioning device in Acute Stroke in 10 participants. Currently enrolling.
1 December 2026
Quick facts
| Lead sponsor | Enrique Leira |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | device feasibility |
| Enrollment | 10 |
| Start date | 1 June 2020 |
| Primary completion | 1 December 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Ischemic conditioning device
Conditions studied
- Acute Stroke — all drugs for Acute Stroke →
Sponsor
Enrique Leira
Who can join
Adults 18 to 80, any sex, with Acute Stroke. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to demonstrate the feasibility of performing remote limb ischemic conditioning (RLIC) using the Doctormate device, a special blood pressure device used to perform RLIC, on patients with acute ischemic stroke due to large vessel occlusion being transported to a thrombectomy capable center by the helicopter.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Induced neuroprotection by remote ischemic perconditioning as a new paradigm in ischemic stroke at the acute phase, a systematic review.
Purroy F, García C, Mauri G, Pereira C, et al · · 2020 · cited 19× · PMID 32615939 · DOI 10.1186/s12883-020-01836-8 -
Interfacility Transfer for Thrombectomy: A Promising Therapeutic Window.
Seners P, Baron JC, Wouters A, Desilles JP, et al · · 2025 · cited 9× · PMID 39502034 · DOI 10.1161/strokeaha.124.049167
Verify or expand the search:
- PubMed search for NCT03481205
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Acute Stroke
Currently open trials in the same condition.
- NCT07491952 — Continuous Dual Aspiration Technique With Zoom System for Stroke · recruiting
- NCT07295366 — Early Administration of PCSK9 Inhibitors After Thrombectomy for Atherosclerotic Acute Ischemic Stroke: A Randomized Cont · Phase 4 · recruiting
- NCT07355881 — mSOAR and Early Mortality in Acute Stroke · recruiting
- NCT07301372 — Evaluation Study of Early Administration of Evolocumab After Thrombolysis in Patients With Atherosclerotic Acute Ischemi · Phase 4 · recruiting
- NCT07167550 — The Study of Efficacy and Safety of Dimephosphon® in Acute Ischemic Stroke · Phase 3 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03481205 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Enrique Leira
- Last refreshed: 10 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03481205.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing