NCT03477045

Does Consuming Modified Plant Seed Oil Containing Fish Oil Fatty Acids Act in the Same Way as Consuming Fish Oil?

Completed NA Last updated 15 June 2022

What this trial tests

NA trial testing Single dose fish oil in Healthy in 31 participants. Completed in 4 November 2019.

Timeline

9 June 2017

Primary endpoint
4 November 2019

4 November 2019

Quick facts

Lead sponsor	University of Southampton
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	basic science
Enrollment	31
Start date	9 June 2017
Primary completion	4 November 2019
Estimated completion	4 November 2019
Sites	1 location across United Kingdom

Drugs / interventions tested

• Single dose fish oil
• Repeated dose fish oil
• single dose Camelina seed oil
• repeated dose camelina seed oil

Conditions studied

• Healthy — all drugs for Healthy →

Sponsor

University of Southampton

Who can join

Adults 18 to 65, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Fish oil and oily fish contain omega 3 long chain polyunsaturated fatty acids known to be beneficial to health. Many people consume little, despite UK government recommendations to eat at least one portion of oily fish per week. Furthermore, despite modest consumption, fish stocks are declining due to over fishing. Therefore, there is a need for an alternative, sustainable and cost efficiently produced dietary source. A seed oil source of these fish oil-type fatty acids has been achieved by adding genes from other plant sources to the oil seed plant Camelina sativa. Camelina sativa, related to mustard and cabbage, has provided seed oil for human consumption for thousands of years. It was the most important oil seed plant in Europe until the 1900's. This research is being done to see if consuming fish oil-type fatty acids in Camelina seed oil allows the body to take up and use the fish oil fatty acids in the same way as it does from fish oil.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. Promising Sources of Plant-Derived Polyunsaturated Fatty Acids: A Narrative Review.
   Rizzo G, Baroni L, Lombardo M. · · 2023 · cited 33× · PMID 36767052 · DOI 10.3390/ijerph20031683
2. Postprandial incorporation of EPA and DHA from transgenic Camelina sativa oil into blood lipids is equivalent to that from fish oil in healthy humans.
   West AL, Miles EA, Lillycrop KA, Han L, et al · · 2019 · cited 24× · PMID 30975228 · DOI 10.1017/s0007114519000825
3. Dietary supplementation with seed oil from transgenic <i>Camelina sativa</i> induces similar increments in plasma and erythrocyte DHA and EPA to fish oil in healthy humans.
   West AL, Miles EA, Lillycrop KA, Han L, et al · · 2020 · cited 18× · PMID 32513312 · DOI 10.1017/s0007114520002044
4. Lipidomic Analysis of Plasma from Healthy Men and Women Shows Phospholipid Class and Molecular Species Differences between Sexes.
   West AL, Michaelson LV, Miles EA, Haslam RP, et al · · 2021 · cited 14× · PMID 33284478 · DOI 10.1002/lipd.12293
5. Dietary Supplementation with Transgenic &lt;i&gt;Camelina sativa&lt;/i&gt; Oil Containing 20:5n-3 and 22:6n-3 or Fish Oil Induces Differential Changes in the Transcriptome of CD3&lt;sup&gt;+&lt;/sup&gt; T Lymphocytes.
   West AL, Miles EA, Han L, Lillycrop KA, et al · · 2021 · cited 2× · PMID 34578993 · DOI 10.3390/nu13093116