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NCT03475095
Motor Control Mechanisms by CNS of Tuina in Patients With Lumbar Disk Herniation
NA trial testing Tuina in Low Back Pain in 90 participants. Status unknown.
31 May 2019
Quick facts
| Lead sponsor | The First Affiliated Hospital of Zhejiang Chinese Medical University |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 90 |
| Start date | 10 March 2018 |
| Primary completion | 31 May 2019 |
| Estimated completion | 31 December 2021 |
| Sites | 1 location across China |
Drugs / interventions tested
- Tuina
Conditions studied
- Low Back Pain — all drugs for Low Back Pain →
- Disc, Herniated — all drugs for Disc, Herniated →
Sponsor
The First Affiliated Hospital of Zhejiang Chinese Medical University
Who can join
Adults 25 to 40, any sex, with Low Back Pain or Disc, Herniated. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Lumbar disk herniation (LDH)is a prevalent health problem around the world. It can cause symptoms of low back pain, numbness or weakness.The understanding of low back pain in traditional Chinese medicine(TCM) theory"unbalanced bones and muscles"that is consistent with the description of modern medicine on LDH function pathology. Tuina is one of Diagnosis and treatment methods in TCM which has been used as a noninvasive treatment of LDH. However, the mechanism of Tuina therapy in LDH is still unclear.The purpose of this study is to establish a platform of the therapeutic effect and mechanical effect of LDH in the treatment of LDH，explore the characteristics of Tuina by the motor control in lumbar CNS,observe the patterns and regularities in the function of related brain regionin of patients with acute or chronic LDH and reveal the mechanism of Tuina of improving the control of lumbar spine CNS movement.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
A spinal manipulative therapy altered brain activity in patients with lumbar disc herniation: A resting-state functional magnetic resonance imaging study.
Wen Y, Chen XM, Jin X, Ling DY, et al · · 2022 · cited 18× · PMID 36161170 · DOI 10.3389/fnins.2022.974792 -
Traditional Chinese Manual Therapy (Tuina) reshape the function of default mode network in patients with lumbar disc herniation.
Chen XM, Wen Y, Chen S, Jin X, et al · · 2023 · cited 14× · PMID 37008205 · DOI 10.3389/fnins.2023.1125677 -
Brain plasticity following lumbar disc herniation treatment with spinal manipulation therapy based on resting-state functional magnetic resonance imaging.
Du HG, Wen Y, Dong JX, Chen S, et al · · 2024 · cited 2× · PMID 39315226 · DOI 10.1016/j.heliyon.2024.e37703
Verify or expand the search:
- PubMed search for NCT03475095
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other The First Affiliated Hospital of Zhejiang Chinese Medical University trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03475095 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The First Affiliated Hospital of Zhejiang Chinese Medical University
- Last refreshed: 23 March 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03475095.
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