Who is sponsoring NCT03472677?

NCT03472677 is sponsored by Centrexion Therapeutics.

What drugs are being tested in NCT03472677?

Interventions in NCT03472677: Ice Pack and Cooling Device, CNTX-4975-05 (trans-capsaicin), CNTX-4975-05 (trans-capsaicin), CNTX-4975-05 (trans-capsaicin), Capsaicin.

What condition does NCT03472677 study?

NCT03472677 studies Osteoarthritis, Knee.

Is NCT03472677 still recruiting?

NCT03472677 is currently completed. Last updated 19 December 2018.

Last reviewed 2018-12-19 · How we verify

NCT03472677

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of Injection Site Cooling on Pain Experienced After the Administration of CNTX-4975-05 Into the Knee

Completed Phase 1 Last updated 19 December 2018

What this trial tests

Phase 1 trial testing Ice Pack and Cooling Device in Osteoarthritis, Knee in 20 participants. Completed in 3 August 2018.

Timeline

21 March 2018

Primary endpoint
27 July 2018

3 August 2018

Quick facts

Lead sponsor	Centrexion Therapeutics
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	20
Start date	21 March 2018
Primary completion	27 July 2018
Estimated completion	3 August 2018
Sites	1 location across United Kingdom

Drugs / interventions tested

Ice Pack and Cooling Device
CNTX-4975-05 (trans-capsaicin) — full drug profile →
CNTX-4975-05 (trans-capsaicin) — full drug profile →
CNTX-4975-05 (trans-capsaicin) — full drug profile →
Capsaicin (CAPSAICIN) — full drug profile →

Conditions studied

Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →

Sponsor

Centrexion Therapeutics — full company profile →

Who can join

Adults 18 to 75, any sex, with Osteoarthritis, Knee. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A clinical study to measure the effects of injection-site cooling on pain experienced after knee injections of capsaicin in healthy subjects and in patients with knee osteoarthritis.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

An update on targets for treating osteoarthritis pain: NGF and TRPV1.
Obeidat AM, Donner A, Miller RE. · · 2020 · cited 14× · PMID 34178580 · DOI 10.1007/s40674-020-00146-x
TRPV1 Receptor Modulators: Emerging Therapies for Neuropathic, Osteoarthritic, and Perioperative Pain.
Tsai EH, Gan TJ. · · 2026 · PMID 41722000 · DOI 10.1007/s40263-026-01272-1

Verify or expand the search:

Other recruiting trials for Osteoarthritis, Knee

Currently open trials in the same condition.

NCT07509307 — AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee · Phase 3 · recruiting
NCT06488144 — Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans · Phase 3 · recruiting
NCT07386561 — Virtual Reality Therapy and Non-Sleep Deep Rest Relaxation After Joint Arthroplasty · NA · active not recruiting
NCT07514598 — Effect of J-Shaped Incision After Total Knee Arthroplasty (J-TKA) · NA · active not recruiting
NCT07058623 — Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement · NA · recruiting

Other Centrexion Therapeutics trials

Trials by the same sponsor.

NCT04857957 — Safety, Tolerability & Pharmacokinetics Study of CNTX-6016 in Healthy Subjects and Subjects With PDN · Phase 1 · completed
NCT04154501 — A Study to Evaluate the Safety and Pharmacokinetics of CNTX-6016 in Healthy Subjects · Phase 1 · completed
NCT03661996 — An Open-label, 8-week Safety, Efficacy, and Assessment of Cooling Methods for Administration of CNTX-4975-05 for Knee OA · Phase 3 · completed
NCT03660943 — A Clinical Study to Test Efficacy and Safety of Repeat Doses of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain · Phase 3 · completed
NCT03576508 — A Study to Compare Levels of Capsaicin After Intra-Articular Injection and Topical Application in Patients With Painful · Phase 1 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03472677 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Centrexion Therapeutics
Last refreshed: 19 December 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03472677.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing