Who is sponsoring NCT03470675?

NCT03470675 is sponsored by Northwestern University.

What condition does NCT03470675 study?

NCT03470675 studies Pain, Postpartum Depression.

What drugs are being tested in NCT03470675?

Interventions: Epidural saline + IV saline, Epidural morphine 3 mg + IV saline, Epidural morphine 3 mg + IV ketamine 0.3 mg/kg.

What is the status of NCT03470675?

NCT03470675 is currently COMPLETED.

Last reviewed 2025-12-09 · How we verify

Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries

NCT03470675 PHASE4 COMPLETED

Obstetric anal sphincter injuries (OASIS) encompass both third and fourth degree perineal tears. These tears can have a significant impact on women's quality of life in the short and long term. One of the most distressing immediate complications of this severe perineal injury is perineal pain. Women can also experience postpartum depression, dyspareunia, and altered sexual function after OASIS. This is a randomized controlled trial to study the effects of three interventions (placebo, low dose intravenous ketamine plus epidural morphine, or epidural morphine alone) on acute pain after OASIS. The objective of this study is to assess the incidence of perineal pain in postpartum patients 1 week after obstetric anal sphincter injuries.

Details

Lead sponsor	Northwestern University
Phase	PHASE4
Status	COMPLETED
Enrolment	67
Start date	Wed Jun 27 2018 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Thu Jun 20 2024 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Pain
Postpartum Depression

Interventions

Epidural saline + IV saline
Epidural morphine 3 mg + IV saline
Epidural morphine 3 mg + IV ketamine 0.3 mg/kg

Countries

United States