NCT03470571: CMRMyo

CMR Features in Patients With Suspected Myocarditis

Completed Last updated 20 March 2018

What this trial tests

trial testing CMR in Outcome, Fatal in 670 participants. Completed in 1 February 2018.

Timeline

1 June 2016

Primary endpoint
1 April 2017

1 February 2018

Quick facts

Lead sponsor	Brigham and Women's Hospital
Status	Completed
Study type	OBSERVATIONAL
Enrollment	670
Start date	1 June 2016
Primary completion	1 April 2017
Estimated completion	1 February 2018
Sites	1 location across United States

Drugs / interventions tested

• CMR

Conditions studied

• Outcome, Fatal — all drugs for Outcome, Fatal →

Sponsor

Brigham and Women's Hospital

Who can join

18 and older, any sex, with Outcome, Fatal. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Presentation of myocarditis is heterogeneous, often ranges from being asymptomatic, to chest pain, dyspnoea, palpitations, and even sudden cardiac death. Diagnosing myocarditis is challenging with no current uniform clinical gold-standard. CMR is a key investigative tool, however the predictive value of CMR features is unknown. In this study we assess 670 consecutive patients with suspected myocarditis who were referred for CMR between 2002 and 2015 at the BWH. CMR features such as late gadolinium sizing, T1 mapping, extracellular volume fraction assessment, strain analysis (feature tracking), clinical data, labortory tetsings and electrocardiogramm are linked to the outcome in order to assess its predictive value.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Feature Tracking Myocardial Strain Incrementally Improves Prognostication in Myocarditis Beyond Traditional CMR Imaging Features.
   Fischer K, Obrist SJ, Erne SA, Stark AW, et al · · 2020 · cited 109× · PMID 32682718 · DOI 10.1016/j.jcmg.2020.04.025
2. Comparison of myocardial fibrosis quantification methods by cardiovascular magnetic resonance imaging for risk stratification of patients with suspected myocarditis.
   Gräni C, Eichhorn C, Bière L, Kaneko K, et al · · 2019 · cited 79× · PMID 30813942 · DOI 10.1186/s12968-019-0520-0
3. Association of ECG parameters with late gadolinium enhancement and outcome in patients with clinical suspicion of acute or subacute myocarditis referred for CMR imaging.
   Fischer K, Marggraf M, Stark AW, Kaneko K, et al · · 2020 · cited 24× · PMID 31923225 · DOI 10.1371/journal.pone.0227134
4. Reproducibility and its confounders of CMR feature tracking myocardial strain analysis in patients with suspected myocarditis.
   Fischer K, Linder OL, Erne SA, Stark AW, et al · · 2022 · cited 21× · PMID 34932165 · DOI 10.1007/s00330-021-08416-5
5. Prognostic Value of Right Ventricular Function in Patients With Suspected Myocarditis Undergoing Cardiac Magnetic Resonance.
   Bernhard B, Schnyder A, Garachemani D, Fischer K, et al · · 2023 · cited 18× · PMID 36599567 · DOI 10.1016/j.jcmg.2022.08.011
6. Predictive value of cardiac magnetic resonance right ventricular longitudinal strain in patients with suspected myocarditis.
   Bernhard B, Tanner G, Garachemani D, Schnyder A, et al · · 2023 · cited 10× · PMID 37587516 · DOI 10.1186/s12968-023-00957-6
7. Prognostic value of visual and quantitative CMR regional myocardial function in patients with suspected myocarditis.
   Bernhard B, Joss P, Greisser N, Stark AW, et al · · 2024 · cited 4× · PMID 38427272 · DOI 10.1007/s10554-024-03059-1
8. Atrial Function by Long Axis Shortening Enhances Risk Stratification Beyond Traditional CMR Markers in Possible Myocarditis.
   Ciocca N, Brändle D, Riederer L, Fischer K, et al · · 2026 · PMID 42207065 · DOI 10.1016/j.jcmg.2026.04.006