NCT03462654 (LiFE-is-LiFE) is a NA clinical trial of iLiFE in Fall Prevention, sponsored by Heidelberg University.

Who is sponsoring NCT03462654?

NCT03462654 is sponsored by Heidelberg University.

What drugs are being tested in NCT03462654?

Interventions in NCT03462654: iLiFE, gLiFE.

What condition does NCT03462654 study?

NCT03462654 studies Fall Prevention, Exercise.

Is NCT03462654 still recruiting?

NCT03462654 is currently completed. Last updated 25 August 2022.

Last reviewed 2022-08-25 · How we verify

NCT03462654: LiFE-is-LiFE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison of a Group-delivered vs. Individually Delivered 'LiFE' Program

Completed NA Last updated 25 August 2022

What this trial tests

NA trial testing iLiFE in Fall Prevention in 310 participants. Completed in 30 September 2020.

Timeline

5 April 2018

Primary endpoint
5 August 2020

30 September 2020

Quick facts

Lead sponsor	Heidelberg University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	310
Start date	5 April 2018
Primary completion	5 August 2020
Estimated completion	30 September 2020
Sites	2 locations across Germany

Drugs / interventions tested

iLiFE
gLiFE

Conditions studied

Fall Prevention — all drugs for Fall Prevention →
Exercise — all drugs for Exercise →

Sponsor

Heidelberg University

Who can join

70 and older, any sex, with Fall Prevention or Exercise. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In the Lifestyle-Integrated Functional Exercise (LiFE) program, exercises to increase strength and improve balance are embedded into daily life activities. Recurring daily activities and tasks are used as prompts for these exercises so that they are performed multiple times per day. However, implementing the original LiFE program includes high financial requirements and human resources as it comprises one-to-one supervision of participants. Therefore, it is investigated whether implementing LiFE in groups (gLiFE) is not inferior to the individually delivered LiFE (iLiFE) in terms of reducing falls per physical activity. In addition, gLiFE is expected to be more cost-effective as compared to iLiFE. In a multicenter non-inferiority trial, 300 participants aged 70 years or older with confirmed fall risk will be randomized into either the iLiFE or gLiFE arm of the study. Both arms will undergo the same strength and balance exercises and habitualization strategies as described in the LiFE program, however, based on different approaches of delivery (i.e., group vs. individual).

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Exercise for preventing falls in older people living in the community.
Sherrington C, Fairhall NJ, Wallbank GK, Tiedemann A, et al · · 2019 · cited 734× · PMID 30703272 · DOI 10.1002/14651858.cd012424.pub2
Lifestyle-integrated functional exercise to prevent falls and promote physical activity: Results from the LiFE-is-LiFE randomized non-inferiority trial.
Jansen CP, Nerz C, Labudek S, Gottschalk S, et al · · 2021 · cited 20× · PMID 34479573 · DOI 10.1186/s12966-021-01190-z
Comparison of a group-delivered and individually delivered lifestyle-integrated functional exercise (LiFE) program in older persons: a randomized noninferiority trial.
Jansen CP, Nerz C, Kramer F, Labudek S, et al · · 2018 · cited 17× · PMID 30400832 · DOI 10.1186/s12877-018-0953-6
Group or individual lifestyle-integrated functional exercise (LiFE)? A qualitative analysis of acceptability.
Reicherzer L, Kramer-Gmeiner F, Labudek S, Jansen CP, et al · · 2021 · cited 12× · PMID 33522904 · DOI 10.1186/s12877-020-01991-0
Association between everyday walking activity, objective and perceived risk of falling in older adults.
Jansen CP, Klenk J, Nerz C, Todd C, et al · · 2021 · cited 8× · PMID 33710267 · DOI 10.1093/ageing/afab037
Group-Based and Individually Delivered LiFE: Content Evaluation and Predictors of Training Response - A Dose-Response Analysis.
Nerz C, Kramer-Gmeiner F, Jansen CP, Labudek S, et al · · 2022 · cited 7× · PMID 35509348 · DOI 10.2147/cia.s359150
Budget impact analysis of a Lifestyle-integrated Functional Exercise (LiFE) program for older people in Germany: a Markov model based on data from the LiFE-is-LiFE trial.
Dams J, Gottschalk S, Schwenk M, Nerz C, et al · · 2024 · cited 2× · PMID 38395743 · DOI 10.1186/s12877-024-04802-y
Willingness to pay for a group and an individual version of the Lifestyle-integrated Functional Exercise program from a participant perspective.
Gottschalk S, König HH, Schwenk M, Nerz C, et al · · 2022 · cited 2× · PMID 36258179 · DOI 10.1186/s12889-022-14322-2

Verify or expand the search:

Other recruiting trials for Fall Prevention

Currently open trials in the same condition.

NCT07341802 — Pilot Feasibility Study of a Fall Prevention Exercise Programme for Community-dwelling Older Adults in Nanchang, China · NA · recruiting
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NCT07266454 — Evaluating Stumble Recovery Functions of Prosthetic Knees · NA · active not recruiting
NCT06745544 — Impact of Screening and Multicomponent Exercise on Fall Rates, Fractures, and Cardiovascular Health in Diabetes · NA · recruiting
NCT07033897 — Adapting, Implementing and Evaluating the Effectiveness of HARP for People With Disabilities · NA · recruiting

Other Heidelberg University trials

Trials by the same sponsor.

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NCT06018272 — Mentalization-based Treatment Versus Bona-fide Treatment for Patients With Borderline Personality Disorder in Germany · NA · recruiting
NCT06852599 — Long-term Outcomes of Implants in Patients with Periodontitis · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03462654 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Heidelberg University
Last refreshed: 25 August 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03462654.

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