Last reviewed · How we verify
NCT03462277
DNA Methylation and Hydroxymethylation Levels in Patients With Coronary Heart Disease
trial in Coronary Heart Disease in 200 participants. Completed in 1 October 2018.
1 August 2018
Quick facts
| Lead sponsor | Chongqing Medical University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 200 |
| Start date | 1 January 2018 |
| Primary completion | 1 August 2018 |
| Estimated completion | 1 October 2018 |
| Sites | 1 location across China |
Conditions studied
- Coronary Heart Disease — all drugs for Coronary Heart Disease →
Sponsor
Chongqing Medical University
Who can join
65 and older, any sex, with Coronary Heart Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this trial is to investigate the relationship between DNA methylation and hydroxymethylation and the expression of DNMTs, TET family gene and the degree of coronary heart disease.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials.
Shi Y, Zhang H, Huang S, Yin L, et al · · 2022 · cited 233× · PMID 35752619 · DOI 10.1038/s41392-022-01055-2 -
TNAP inhibition attenuates cardiac fibrosis induced by myocardial infarction through deactivating TGF-β1/Smads and activating P53 signaling pathways.
Gao L, Wang LY, Liu ZQ, Jiang D, et al · · 2020 · cited 59× · PMID 31969558 · DOI 10.1038/s41419-020-2243-4 -
Network Medicine: A Clinical Approach for Precision Medicine and Personalized Therapy in Coronary Heart Disease.
Infante T, Del Viscovo L, De Rimini ML, Padula S, et al · · 2020 · cited 30× · PMID 31723086 · DOI 10.5551/jat.52407 -
DNA hydroxymethylation combined with carotid plaques as a novel biomarker for coronary atherosclerosis.
Jiang D, Wang Y, Chang G, Duan Q, et al · · 2019 · cited 12× · PMID 31123222 · DOI 10.18632/aging.101972
Verify or expand the search:
- PubMed search for NCT03462277
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Chongqing Medical University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03462277 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Chongqing Medical University
- Last refreshed: 17 July 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03462277.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing