NCT03457870 (ChANgE) is a NA clinical trial of Intermittent Energy Restriction in Aging, sponsored by King's College London.

Who is sponsoring NCT03457870?

NCT03457870 is sponsored by King's College London.

What drugs are being tested in NCT03457870?

Interventions in NCT03457870: Intermittent Energy Restriction, Chewing, Chewing + Intermittent Energy Restriction.

What condition does NCT03457870 study?

NCT03457870 studies Aging, Cognitive Decline.

Is NCT03457870 still recruiting?

NCT03457870 is currently completed. Last updated 18 February 2021.

Last reviewed 2021-02-18 · How we verify

NCT03457870: ChANgE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Intermittent Energy Restriction and Chewing on Neural Stem Cell Ageing and Adult Hippocampal Neurogenesis Associated Cognition

Completed NA Last updated 18 February 2021

What this trial tests

NA trial testing Intermittent Energy Restriction in Aging in 123 participants. Completed in 23 March 2020.

Timeline

18 April 2018

Primary endpoint
23 March 2020

23 March 2020

Quick facts

Lead sponsor	King's College London
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	123
Start date	18 April 2018
Primary completion	23 March 2020
Estimated completion	23 March 2020
Sites	1 location across United Kingdom

Drugs / interventions tested

Intermittent Energy Restriction
Chewing
Chewing + Intermittent Energy Restriction

Conditions studied

Aging — all drugs for Aging →
Cognitive Decline — all drugs for Cognitive Decline →

Sponsor

King's College London

Who can join

60 and older, female only, with Aging or Cognitive Decline. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Extended bouts of periodic mastication and intermittent energy restriction (IER) may improve cognitive performance in the context of adult hippocampal neurogenesis in an ageing population. A randomised controlled parallel design trial will determine the impact of a 3 month IER diet (2 consecutive days of very low calorie diet and 5 days of normal eating) and a mastication intervention (1 piece of gum chewed for 10 minutes 3 times a day) in comparison to a control on neurogenesis-associated cognitive measures and circulating levels of the anti-ageing protein Klotho.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Recent clinical trials with stem cells to slow or reverse normal aging processes.
Garay RP. · · 2023 · cited 14× · PMID 37090485 · DOI 10.3389/fragi.2023.1148926
Emerging Pro-neurogenic Therapeutic Strategies for Neurodegenerative Diseases: A Review of Pre-clinical and Clinical Research.
Vassal M, Martins F, Monteiro B, Tambaro S, et al · · 2025 · cited 12× · PMID 38816676 · DOI 10.1007/s12035-024-04246-w
Current understanding and prospects for targeting neurogenesis in the treatment of cognitive impairment.
Liu Y, Ding X, Jia S, Gu X. · · 2026 · cited 10× · PMID 39820472 · DOI 10.4103/nrr.nrr-d-24-00802

Verify or expand the search:

Other trials of Intermittent Energy Restriction

Trials testing the same drug.

NCT03998878 — Testing the Effect of Multiple Weight Management Modalities for Chronic Disease Risk Reduction in a Clinical Setting · NA · completed

Other recruiting trials for Aging

Currently open trials in the same condition.

NCT02831335 — Technical Development of Multi-Parametric Renocerebral MRI · recruiting
NCT07099053 — Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging · recruiting
NCT07504068 — Effects of Physical Exercise and a Nutritional Supplement on Body Composition, Metabolic Function, and Overall Health in · NA · recruiting
NCT07525453 — Effects of Three Different Exercise Programs on Dynamic Balance in Community-Dwelling Older Adults · NA · recruiting
NCT07500727 — Skeletal Muscle Aging and Responsiveness in Aged People With MS · NA · recruiting

Other King's College London trials

Trials by the same sponsor.

NCT07357064 — Professional Decision Making in Childbirth. · not yet recruiting
NCT07341087 — Skin Inflammation in Perimenopause: A Probiotic Intervention Proof of Concept Trial · NA · recruiting
NCT07228962 — Cutaneous Biomarkers in Atopic Eczema Using a Non-Invasive Micro-Suction Device in Babies · not yet recruiting
NCT07365722 — Comparison of Two Non-surgical Procedure to Manage Gum Disease Around Implants. · NA · not yet recruiting
NCT07378488 — Dance/Movement Therapy for Functional Neurological Disorder · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03457870 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by King's College London
Last refreshed: 18 February 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03457870.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing