NCT03455010 (COMP) is a NA clinical trial of Increased load in Healthy, sponsored by University Hospital, Basel, Switzerland.

Who is sponsoring NCT03455010?

NCT03455010 is sponsored by University Hospital, Basel, Switzerland.

What drugs are being tested in NCT03455010?

Interventions in NCT03455010: Increased load, Reduced load.

Is NCT03455010 still recruiting?

NCT03455010 is currently completed. Last updated 18 September 2019.

Last reviewed 2019-09-18 · How we verify

NCT03455010: COMP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Dose-Response Relationship of Ambulatory Load and Cartilage - Pilot Study

Completed NA Last updated 18 September 2019

What this trial tests

NA trial testing Increased load in Healthy in 24 participants. Completed in 31 July 2019.

Timeline

5 July 2017

Primary endpoint
30 September 2017

31 July 2019

Quick facts

Lead sponsor	University Hospital, Basel, Switzerland
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	basic science
Enrollment	24
Start date	5 July 2017
Primary completion	30 September 2017
Estimated completion	31 July 2019
Sites	1 location across Switzerland

Drugs / interventions tested

Increased load
Reduced load

Conditions studied

Healthy — all drugs for Healthy →

Sponsor

University Hospital, Basel, Switzerland

Who can join

Adults 18 to 30, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The research question is if there is a dose-response relationship between blood biomarkers for articular cartilage and the magnitude of physiological load. To investigate this load induced biomarker change, the participants will complete a 30-minute walking test under three loading conditions: A: 80%, B: 100% C: 120% of their respective bodyweight (Fig. 1). The main biomarker we are interested in is called cartilage oligomeric matrix protein (COMP). Serum COMP levels are increased immediately after 30-min running but there is no dose-response relationship shown yet.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Experimental-analytical approach to assessing mechanosensitive cartilage blood marker kinetics in healthy adults: dose-response relationship and interrelationship of nine candidate markers.
Herger S, Vach W, Liphardt AM, Nüesch C, et al · · 2021 · cited 6× · PMID 35284064 · DOI 10.12688/f1000research.52159.2

Verify or expand the search:

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Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03455010 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Basel, Switzerland
Last refreshed: 18 September 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03455010.

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