NCT03453463

Exercise Effects on Sarco-Osteopenia in Older Men

Completed NA Last updated 4 November 2020

What this trial tests

NA trial testing exercise in Sarcopenia in 43 participants. Completed in 1 October 2020.

Timeline

15 January 2018

Primary endpoint
18 August 2020

1 October 2020

Quick facts

Lead sponsor	University of Erlangen-Nürnberg Medical School
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	43
Start date	15 January 2018
Primary completion	18 August 2020
Estimated completion	1 October 2020
Sites	1 location across Germany

Drugs / interventions tested

• exercise

Conditions studied

• Sarcopenia — all drugs for Sarcopenia →
• Osteopenia — all drugs for Osteopenia →

Sponsor

University of Erlangen-Nürnberg Medical School

Who can join

70 and older, male only, with Sarcopenia or Osteopenia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The study determined the effects of predominately resistance type exercise in combination with protein supplements on parameters of sarcopenia and osteopenia (sarco-osteopenia) in older, community dwelling men with sarcopenia and -osteopenia over 18 months.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Molecular mechanisms of exercise contributing to tissue regeneration.
   Chen J, Zhou R, Feng Y, Cheng L. · · 2022 · cited 90× · PMID 36446784 · DOI 10.1038/s41392-022-01233-2
2. The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study.
   Lichtenberg T, von Stengel S, Sieber C, Kemmler W. · · 2019 · cited 63× · PMID 31908428 · DOI 10.2147/cia.s225618
3. Effects of High Intensity Dynamic Resistance Exercise and Whey Protein Supplements on Osteosarcopenia in Older Men with Low Bone and Muscle Mass. Final Results of the Randomized Controlled FrOST Study.
   Kemmler W, Kohl M, Jakob F, Engelke K, et al · · 2020 · cited 49× · PMID 32764397 · DOI 10.3390/nu12082341
4. Effects of 16 months of high intensity resistance training on thigh muscle fat infiltration in elderly men with osteosarcopenia.
   Ghasemikaram M, Chaudry O, Nagel AM, Uder M, et al · · 2021 · cited 23× · PMID 33449309 · DOI 10.1007/s11357-020-00316-8
5. High Intensity Resistance Exercise Training to Improve Body Composition and Strength in Older Men With Osteosarcopenia. Results of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST).
   Kemmler W, Weineck M, Kohl M, von Stengel S, et al · · 2020 · cited 20× · PMID 33344999 · DOI 10.3389/fspor.2020.00004
6. Changes in Body Composition and Cardiometabolic Health After Detraining in Older Men with Osteosarcopenia: 6-Month Follow-Up of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST) Study.
   Kemmler W, Schoene D, Kohl M, von Stengel S. · · 2021 · cited 14× · PMID 33854307 · DOI 10.2147/cia.s299867
7. Detraining effects after 18 months of high intensity resistance training on osteosarcopenia in older men-Six-month follow-up of the randomized controlled Franconian Osteopenia and Sarcopenia Trial (FrOST).
   Kemmler W, Kohl M, Fröhlich M, Schoene D, et al · · 2021 · cited 11× · PMID 33249320 · DOI 10.1016/j.bone.2020.115772
8. Detraining Effects on Muscle Quality in Older Men with Osteosarcopenia. Follow-Up of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST).
   Ghasemikaram M, Engelke K, Kohl M, von Stengel S, et al · · 2021 · cited 9× · PMID 34062828 · DOI 10.3390/nu13051528