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NCT03447093
The Oral Microbiota in Autoimmune Thyroiditis is Distinctive And Predictive
trial testing Methimazole Pill in Microbiota in 120 participants. Status unknown.
1 December 2019
Quick facts
| Lead sponsor | First Affiliated Hospital of Harbin Medical University |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 120 |
| Start date | 23 December 2017 |
| Primary completion | 1 December 2019 |
| Estimated completion | 1 December 2021 |
| Sites | 1 location across China |
Drugs / interventions tested
- Methimazole Pill — full drug profile →
- Propylthiouracil Pill — full drug profile →
Conditions studied
- Microbiota — all drugs for Microbiota →
Sponsor
First Affiliated Hospital of Harbin Medical University
Who can join
Adults 18 to 65, any sex, with Microbiota. Healthy volunteers can join.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
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Transcriptional changes in oral microbiota
Time frame: Baseline, 3 months, 6 months, 9 months, 12 months
The microbiota measured by 16S rRNA gene
Sponsor's own description
Autoimmune thyroiditis (AITD) mainly includes Hashimoto's thyroiditis (HT) and Grave's disease (GD). Studies have shown that autoimmune thyroiditis is closely related to microbial disorders such as autoimmune thyroiditis However, there is no report on the relationship between oral microecology and autoimmune thyroiditis. Therefore, our group will study the correlation between oral microbiota and AITD.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
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Medical Applications of Molecular Biotechnologies in the Context of Hashimoto's Thyroiditis.
Trovato M, Valenti A. · · 2023 · cited 1× · PMID 37371008 · DOI 10.3390/diagnostics13122114
Verify or expand the search:
- PubMed search for NCT03447093
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Methimazole Pill
Trials testing the same drug.
- NCT03433352 — Intestinal Microbiota and Treatment of GD · unknown
- NCT03390582 — Gut Microbiota is Associated With Autoimmune Thyroid Disease · unknown
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Currently open trials in the same condition.
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- NCT07154173 — Comprehensive Analysis of Gut Microbiota Signatures in Metastatic Colorectal Cancer · recruiting
Other First Affiliated Hospital of Harbin Medical University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03447093 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by First Affiliated Hospital of Harbin Medical University
- Last refreshed: 25 February 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03447093.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing