Intrauterine Injection of Human Chorionic Gonadotrophin and Pregnancy Rate in ICSI

NCT03445910 NA COMPLETED

Despite recent advances in clinical and laboratory techniques of Assisted Reproductive Technology (ART), the pregnancy rate remains around 30% per cycle. It has been estimated that 50% to 75% of lost pregnancies are due to failure of implantation. The process of implantation is a locally controlled paracrine/juxtacrine-mediated phenomenon. Successful implantation depends on the synchronized "cross-talk" between a functional blastocyst and a "receptive" endometrium. This process leads to apposition, attachment and invasion of embryos and subsequent normal placentation. So the objective of this study is investigate the impact of intrauterine injection of human chorionic gonadotropin (hCG) at the day of ovum pick-up on implantation and pregnancy rates in patients with recurrent implantation failure.

Details

Lead sponsor	Ain Shams University
Phase	NA
Status	COMPLETED
Enrolment	100
Start date	Tue Feb 20 2018 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Mon Jul 30 2018 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Repeated Implantation Failure

Interventions

• Human chorionic gonadotropin

Countries

Egypt