NCT03443102

Long-term Assessment of Organ Functions Among Survivors of Severe Acute Respiratory Syndrome

Status unknown Last updated 26 February 2018

What this trial tests

trial in SARS Virus in 150 participants. Status unknown.

Timeline

25 January 2018

Primary endpoint
1 July 2018

1 December 2018

Quick facts

Lead sponsor	Peking University People's Hospital
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	150
Start date	25 January 2018
Primary completion	1 July 2018
Estimated completion	1 December 2018
Sites	1 location across China

Conditions studied

• SARS Virus — all drugs for SARS Virus →
• Long-Term Survivors — all drugs for Long-Term Survivors →

Sponsor

Peking University People's Hospital

Who can join

Eligibility, any sex, with SARS Virus or Long-Term Survivors. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

SARS-CoV has caused severe epidemic respiratory disease in human populations. By July 2003, a total of 8,096 probable cases of SARS had been reported including 774 deaths in 27 countries, around one-third of which were health care workers (HCWs). Previous studies have been reported about long-term impacts of SARS infection, including lung function deficiency, steroid-induced osteonecrosis, reduced exercise capacity, and impairment in health-related quality of life (HRQoL). HCWs, especially nurses, have been reported to experience greater psychological distress, particularly increased levels of posttraumatic stress symptomatology (PTSS). But the very complex impacts of this fatal infection on HCWs have not been fully elucidated. It is thus important to follow these occupational patients to detect and manage multi-organ sequelae and functional impairment.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. Long-term bone and lung consequences associated with hospital-acquired severe acute respiratory syndrome: a 15-year follow-up from a prospective cohort study.
   Zhang P, Li J, Liu H, Han N, et al · · 2020 · cited 315× · PMID 32128276 · DOI 10.1038/s41413-020-0084-5
2. Investigation of the impact of SARS-CoV infection on the immunologic status and lung function after 15 years.
   Li J, Zheng Y, Zhao L, Yue Z, et al · · 2021 · cited 4× · PMID 34819019 · DOI 10.1186/s12879-021-06881-3
3. Investigation of the Impact of SARS-CoV-1 Infection on the Immunologic Status and Lung Function After 15 Years
   Li J, Zheng Y, Zhao L, Yue Z, et al · · 2021 · DOI 10.21203/rs.3.rs-386485/v1
4. Long-term consequences in lung and bone associated with hospital-acquired severe acute respiratory syndrome: a 15-year follow-up from a prospective cohort study
   Zhang P, Li J, Han N, Liu H, et al · · 2018