NCT03441750 (ChinaDPP) is a Phase 4 clinical trial of metformin in PreDiabetes, sponsored by Chinese Association of Geriatric Research.

Who is sponsoring NCT03441750?

NCT03441750 is sponsored by Chinese Association of Geriatric Research.

What drugs are being tested in NCT03441750?

Interventions in NCT03441750: metformin, Standard lifestyle intervention.

What condition does NCT03441750 study?

NCT03441750 studies PreDiabetes.

Is NCT03441750 still recruiting?

NCT03441750 is currently completed. Last updated 15 November 2021.

Last reviewed 2021-11-15 · How we verify

NCT03441750: ChinaDPP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Efficacy of Metformin in Preventing Diabetes in China

Completed Phase 4 Last updated 15 November 2021

What this trial tests

Phase 4 trial testing metformin in PreDiabetes in 1,724 participants. Completed in 30 June 2021.

Timeline

25 April 2017

Primary endpoint
30 June 2021

30 June 2021

Quick facts

Lead sponsor	Chinese Association of Geriatric Research
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	1,724
Start date	25 April 2017
Primary completion	30 June 2021
Estimated completion	30 June 2021
Sites	1 location across China

Drugs / interventions tested

metformin (metformin) — full drug profile →
Standard lifestyle intervention

Conditions studied

PreDiabetes — all drugs for PreDiabetes →

Sponsor

Chinese Association of Geriatric Research

Who can join

Adults 18 to 70, any sex, with PreDiabetes. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A multicentred, randomized, open study to evaluate the efficacy of metformin in preventing Diabetes.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

Safety and effectiveness of metformin plus lifestyle intervention compared with lifestyle intervention alone in preventing progression to diabetes in a Chinese population with impaired glucose regulation: a multicentre, open-label, randomised controlled trial.
Zhang L, Zhang Y, Shen S, Wang X, et al · · 2023 · cited 53× · PMID 37414069 · DOI 10.1016/s2213-8587(23)00132-8
Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus.
Madsen KS, Chi Y, Metzendorf MI, Richter B, et al · · 2019 · cited 35× · PMID 31794067 · DOI 10.1002/14651858.cd008558.pub2
Metabolic Alteration Bridging the Prediabetic State and Colorectal Cancer.
Colloca A, Donisi I, Anastasio C, Balestrieri ML, et al · · 2024 · cited 8× · PMID 38667278 · DOI 10.3390/cells13080663
58<sup>th</sup> EASD Annual Meeting of the European Association for the Study of Diabetes : Stockholm, Sweden, 19 - 23 September 2022.
· 2022 · cited 6× · PMID 35920845 · DOI 10.1007/s00125-022-05755-w
Efficacy of metformin in preventing progression to diabetes in a Chinese population with impaired glucose regulation: Protocol for a multicentre, open-label, randomized controlled clinical study.
Ji L, Sun N, Zhang Y, Zhang L, et al · · 2020 · cited 5× · PMID 31512365 · DOI 10.1111/dom.13884
External validation and application of a machine learning-based model for diabetes progression in prediabetes.
Wang S, Huang Q, Luo Y, Luo Y, et al · · 2026 · PMID 41948552 · DOI 10.3389/fendo.2026.1746570

Verify or expand the search:

Other trials of metformin

Trials testing the same drug.

NCT06463743 — Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS) · Phase 2 · recruiting
NCT06679413 — A Study to Assess Drug-drug Interaction of ZX008 in Healthy Male and Female Study Participants · Phase 1 · completed
NCT05966792 — SGLT2 Inhibitors in Treating Patients With PCOS · NA · completed
NCT05767515 — The Effects of Acetyl-L-Carnitine and Myo/Chiro-Inositol in Patients With PCOS · NA · completed
NCT05815680 — A Study to Evaluate the Drug-drug Interactions (DDIs) of IBI362 With Metformin, Warfarin, Atorvastatin, Digoxin in Overw · Phase 1 · completed

Other recruiting trials for PreDiabetes

Currently open trials in the same condition.

NCT06897982 — Feasibility of a Nutrition Intervention for Patients With Prediabetes at a Federally Qualified Health Center · NA · recruiting
NCT06967558 — The Role of Islet GLP-1 in the Pathogenesis of Prediabetes · Phase 2 · recruiting
NCT06482944 — Whole Food for Families: A Pilot RCT of a Dietary Guidelines-Based Intervention to Prevent Type 2 Diabetes · NA · recruiting
NCT06989164 — Post Prandial Individual Responses to Different Foods · NA · recruiting
NCT07254572 — Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetes · Phase 4 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03441750 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Chinese Association of Geriatric Research
Last refreshed: 15 November 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03441750.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing