NCT03441399 (ADAPT) is a NA clinical trial of Financial incentives in Depression, sponsored by University of Pennsylvania.

Who is sponsoring NCT03441399?

NCT03441399 is sponsored by University of Pennsylvania.

What drugs are being tested in NCT03441399?

Interventions in NCT03441399: Financial incentives.

What condition does NCT03441399 study?

NCT03441399 studies Depression.

Is NCT03441399 still recruiting?

NCT03441399 is currently completed. Last updated 15 October 2019.

Last reviewed 2019-10-15 · How we verify

NCT03441399: ADAPT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparing Differing Financial Incentive Structures for Increasing Antidepressant Adherence Among Adults

Completed NA Last updated 15 October 2019

What this trial tests

NA trial testing Financial incentives in Depression in 120 participants. Completed in 26 September 2019.

Timeline

1 March 2018

Primary endpoint
26 September 2019

26 September 2019

Quick facts

Lead sponsor	University of Pennsylvania
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	health services research
Enrollment	120
Start date	1 March 2018
Primary completion	26 September 2019
Estimated completion	26 September 2019
Sites	1 location across United States

Drugs / interventions tested

Financial incentives

Conditions studied

Depression — all drugs for Depression →

Sponsor

University of Pennsylvania

Who can join

Adults 21 to 64, any sex, with Depression. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The investigators will test using financial incentives by leveraging decision-making biases to improve adherence to antidepressants among adults newly prescribed antidepressants. This study will compare the effects of usual care, increasing financial incentives, and decreasing financial incentives on daily antidepressant medication adherence and depression symptom control of non-elderly adults with Major Depressive Disorder.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Transforming Mental Health Delivery Through Behavioral Economics and Implementation Science: Protocol for Three Exploratory Projects.
Beidas RS, Volpp KG, Buttenheim AN, Marcus SC, et al · · 2019 · cited 20× · PMID 30747719 · DOI 10.2196/12121
Effect of Escalating and Deescalating Financial Incentives vs Usual Care to Improve Antidepressant Adherence: A Pilot Randomized Clinical Trial.
Marcus SC, Reilly ME, Zentgraf K, Volpp KG, et al · · 2021 · cited 11× · PMID 32965464 · DOI 10.1001/jamapsychiatry.2020.3000

Verify or expand the search:

Other trials of Financial incentives

Trials testing the same drug.

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NCT05322044 — Financial Incentives to Improve Asthma · NA · completed
NCT04902326 — Behavioral Economics and Self-Determination Theory to Change Diabetes Risk (BEST Change) · NA · completed
NCT04917926 — Behavioural Economics-based Incentives in Adults With Type 2 Diabetes (BET2) · NA · completed
NCT04445662 — Financial Incentives for Homeless Smokers: A Community-based RCT · NA · completed

Other recruiting trials for Depression

Currently open trials in the same condition.

NCT07336238 — Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or · Phase 2 · recruiting
NCT06906939 — A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression · EARLY_PHASE1 · recruiting
NCT07517549 — Sexual Health Education During Pregnancy · NA · recruiting
NCT06408246 — ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in Depression · Phase 2 · recruiting
NCT07449676 — Effects of an Innovative TCM-based Tui Jing Therapy on Psychological and Neurophysiological Functions in Depression · NA · recruiting

Other University of Pennsylvania trials

Trials by the same sponsor.

NCT06081153 — Mechanistic Clinical Trial of PCSK9 Inhibition for AAA · EARLY_PHASE1 · not yet recruiting
NCT07415772 — Effect of cTBS on Startle and TMS-evoked BOLD · NA · not yet recruiting
NCT07489430 — DaxibotulinumtoxinA for Blepharospasm · Phase 2 · not yet recruiting
NCT07463131 — Negative Income Tax Trial · NA · not yet recruiting
NCT06645769 — Na-Phenylbutyrate VAscular Trial · EARLY_PHASE1 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03441399 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Pennsylvania
Last refreshed: 15 October 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03441399.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing