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Avelumab, Utomilumab, Rituximab, Ibrutinib, and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma or Mantle Cell Lymphoma
This phase I trial studies the side effects and best dose of avelumab, utomilumab, rituximab, ibrutinib, and combination chemotherapy in treating patients with diffuse large B-cell lymphoma or mantle cell lymphoma that has come back or does not respond to treatment. Monoclonal antibodies, such as avelumab, utomilumab, and rituximab, may interfere with the ability of tumor cells to grow and spread. Ibrutinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as etoposide phosphate, carboplatin, and ifosfamide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving avelumab, utomilumab, rituximab, ibrutinib, and combination chemotherapy may work better in treating patients with diffuse large B-cell lymphoma or mantle cell lymphoma.
Details
| Lead sponsor | City of Hope Medical Center |
|---|---|
| Phase | PHASE1 |
| Status | COMPLETED |
| Enrolment | 16 |
| Start date | Mon Apr 02 2018 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Wed Jun 26 2024 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Recurrent Diffuse Large B-Cell Lymphoma
- Recurrent Mantle Cell Lymphoma
- Refractory Diffuse Large B-Cell Lymphoma
- Refractory Mantle Cell Lymphoma
- Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma
Interventions
- Autologous Hematopoietic Stem Cell Transplantation
- Avelumab
- Carboplatin
- Etoposide Phosphate
- Ibrutinib
- Ifosfamide
- Laboratory Biomarker Analysis
- Rituximab
- Utomilumab
Countries
United States