NCT03438968

Women in Cardiac Rehabilitation: Optimizing the Training Response

Status unknown NA Last updated 20 February 2018

What this trial tests

NA trial testing Exercise training in Exercise Training in 40 participants. Status unknown.

Timeline

24 August 2017

Primary endpoint
31 December 2018

30 April 2019

Quick facts

Lead sponsor	University of Vermont
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	40
Start date	24 August 2017
Primary completion	31 December 2018
Estimated completion	30 April 2019
Sites	1 location across United States

Drugs / interventions tested

• Exercise training

Conditions studied

• Exercise Training — all drugs for Exercise Training →
• Coronary Artery Disease — all drugs for Coronary Artery Disease →
• Women — all drugs for Women →
• Cardiac Rehabilitation — all drugs for Cardiac Rehabilitation →

Sponsor

University of Vermont

Who can join

18 and older, female only, with Exercise Training or Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Cardiovascular disease (CVD) is highly prevalent in women resulting in 398,086 deaths annually. Even as women participate in traditional CR programs, data specificity and subsequent research have yet to emerge in a meaningful way so that women-centered CR can be better customized and their outcomes properly assessed. Aerobic fitness is a powerful predictor of prognosis in individuals with CVD yet there is evidence that women do not improve their peak VO2 as much as men during CR. We have designed a training program for women based upon past research with a goal of optimizing their training potential in CR. This program combines the utilization of a training technique termed high intensity interval training along with specific strength training exercises of the upper legs. We hypothesize that women, irrespective of age, would be capable of high intensity interval training to improve peak aerobic capacity in the CR setting. Furthermore, since women often have a deficit of thigh strength entering CR, and thigh strength correlates with endurance walking,strength training will also be included. The purpose of this study is to examine the value of high intensity interval training and strength training to maximize aerobic training response in CR for women. This may contribute to establishing specific protocols and training guidelines for future program design for women in CR. Since a set of comprehensive CR guidelines pertaining to women is lacking, it is hoped that the results of this study will help us develop exercise protocols and regimen to better structure and modulate CR programs for optimal benefit to women.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Optimizing Training Response for Women in Cardiac Rehabilitation: A Randomized Clinical Trial.
   Khadanga S, Savage PD, Pecha A, Rengo J, et al · · 2022 · cited 24× · PMID 34817540 · DOI 10.1001/jamacardio.2021.4822