NCT03438812 is a NA clinical trial of dehydroepiandrosterone (DHEA) in Poor Responders, sponsored by Kaohsiung Veterans General Hospital..

Who is sponsoring NCT03438812?

NCT03438812 is sponsored by Kaohsiung Veterans General Hospital..

What drugs are being tested in NCT03438812?

Interventions in NCT03438812: dehydroepiandrosterone (DHEA).

What condition does NCT03438812 study?

NCT03438812 studies Poor Responders, Dehydroepiandrosterone.

Is NCT03438812 still recruiting?

NCT03438812 is currently completed. Last updated 18 February 2021.

Last reviewed 2021-02-18 · How we verify

NCT03438812

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Dehydroepiandrosterone Maintain Mitochondrial Quality of Cumulus Cells in Poor Ovarian Responders

Completed NA Last updated 18 February 2021

What this trial tests

NA trial testing dehydroepiandrosterone (DHEA) in Poor Responders in 66 participants. Completed in 31 December 2019.

Timeline

6 September 2017

Primary endpoint
31 December 2019

31 December 2019

Quick facts

Lead sponsor	Kaohsiung Veterans General Hospital.
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	66
Start date	6 September 2017
Primary completion	31 December 2019
Estimated completion	31 December 2019
Sites	1 location across Taiwan

Drugs / interventions tested

dehydroepiandrosterone (DHEA) — full drug profile →

Conditions studied

Poor Responders — all drugs for Poor Responders →
Dehydroepiandrosterone — all drugs for Dehydroepiandrosterone →

Sponsor

Kaohsiung Veterans General Hospital.

Who can join

Adults 25 to 45, female only, with Poor Responders or Dehydroepiandrosterone. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To investigate whether the DHEA supplementation could improve mitochondrial quality in poor ovarian responders

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Phosphoglycerate mutase family member 5 maintains oocyte quality via mitochondrial dynamic rearrangement during aging.
Li CJ, Lin LT, Tsai HW, Wen ZH, et al · · 2022 · cited 48× · PMID 34995407 · DOI 10.1111/acel.13546
Dehydroepiandrosterone Shifts Energy Metabolism to Increase Mitochondrial Biogenesis in Female Fertility with Advancing Age.
Li CJ, Lin LT, Tsui KH. · · 2021 · cited 26× · PMID 34371958 · DOI 10.3390/nu13072449
Dehydroepiandrosterone Ameliorates Abnormal Mitochondrial Dynamics and Mitophagy of Cumulus Cells in Poor Ovarian Responders.
Li CJ, Chen SN, Lin LT, Chern CU, et al · · 2018 · cited 20× · PMID 30241351 · DOI 10.3390/jcm7100293
Abstracts for 2018 Foundation for Reproductive Medicine Translational Reproductive Biology and Clinical Reproductive Endocrinology Conference.
· 2018 · PMID 30317467 · DOI 10.1007/s10815-018-1321-3

Verify or expand the search:

Other recruiting trials for Poor Responders

Currently open trials in the same condition.

NCT06663930 — New Approach for Ovarian PRP Injection for Poor Responders · active not recruiting
NCT04487925 — Controlled Ovarian Stimulation Versus Modified Natural Cycles in Poor Responders · Phase 4 · recruiting

Other Kaohsiung Veterans General Hospital. trials

Trials by the same sponsor.

NCT07278024 — Postbiotic Intervention on Vaginal Microbiota · NA · completed
NCT07051265 — Effect of Transcutaneous Electrical Nerve Stimulation or Acupressure on Pain in Patients With Head and Neck Cancer · NA · enrolling by invitation
NCT06777758 — Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments · Phase 4 · recruiting
NCT06803199 — Effects of LH and FSH on Metabolic Regulation in Cumulus Cells · NA · recruiting
NCT06946888 — Effects of Acupressure on Nurses' Psychological Distress, Depression, Job Stress, Occupational Burnout, and Resilience · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03438812 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Kaohsiung Veterans General Hospital.
Last refreshed: 18 February 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03438812.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing