NCT03437538 is a NA clinical trial of MCO-HD in Chronic Kidney Failure, sponsored by Region Skane.

Who is sponsoring NCT03437538?

NCT03437538 is sponsored by Region Skane.

What drugs are being tested in NCT03437538?

Interventions in NCT03437538: MCO-HD, High-flux HDF.

What condition does NCT03437538 study?

NCT03437538 studies Chronic Kidney Failure, Uremia, Dialysis.

Is NCT03437538 still recruiting?

NCT03437538 is currently completed. Last updated 13 November 2019.

Last reviewed 2019-11-13 · How we verify

NCT03437538

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Reduction Ratio and Clearance During Hemodialysis With MCO-filter Compared to HDF With Standard High-flux Filter

Completed NA Last updated 13 November 2019

What this trial tests

NA trial testing MCO-HD in Chronic Kidney Failure in 18 participants. Completed in 16 April 2019.

Timeline

21 May 2018

Primary endpoint
16 April 2019

16 April 2019

Quick facts

Lead sponsor	Region Skane
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	crossover
Masking	none
Primary purpose	treatment
Enrollment	18
Start date	21 May 2018
Primary completion	16 April 2019
Estimated completion	16 April 2019
Sites	1 location across Sweden

Drugs / interventions tested

MCO-HD
High-flux HDF

Conditions studied

Chronic Kidney Failure — all drugs for Chronic Kidney Failure →
Uremia — all drugs for Uremia →
Dialysis — all drugs for Dialysis →

Sponsor

Region Skane — full company profile →

Who can join

18 and older, any sex, with Chronic Kidney Failure or Uremia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The Medium Cut-Off dialysis (MCO) membrane has been developed to improve middle molecule removal compared to standard high-flux dialysis filters. The major aim of this study is to compare the reduction ratio of middle molecules, during a single hemodialysis session with MCO-filter, compared to hemodiafiltration (HDF) with standard high-flux filter. Secondary aims are to compare the reduction ratio of small and large molecules between the treatments.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Comparison of Hemodialysis Using a Medium Cutoff Dialyzer versus Hemodiafiltration: A Controlled Cross-Over Study.
Lindgren A, Fjellstedt E, Christensson A. · · 2020 · cited 16× · PMID 33149656 · DOI 10.2147/ijnrd.s263110

Verify or expand the search:

Other recruiting trials for Chronic Kidney Failure

Currently open trials in the same condition.

NCT07348237 — A Clinical Trial of MK-2828 in People With Kidney Disease (MK-2828-006) · Phase 1 · recruiting
NCT06981585 — Physical Impairments in Children With Chronic Renal Failure · recruiting
NCT06660160 — Group Exercise Program Supported By Audiovisual Media During Hemodialysis · NA · active not recruiting
NCT05562869 — Belatacept as a Replacement for CNIs 3 to 12 Months Post-transplantation in Patients With Early Graft Dysfunction · Phase 3 · recruiting
NCT05445219 — Identifying Therapeutic Hemodialysis Targets Through Cerebrovascular Reactivity; RESPIRACT 2 · active not recruiting

Other Region Skane trials

Trials by the same sponsor.

NCT07511673 — The Study is a Randomised Clinical Trial (RCT) to Test if Preoperative Dental Screening is Superior to no Preoperative D · NA · not yet recruiting
NCT07169747 — Safety, Therapeutic Potential, and Mechanisms of Two Psilocybin Doses, Administered With Psychological Support in Young · Phase 2 · recruiting
NCT07494669 — Proteomics and Physiological Parameters Predicting Complications After Colorectal Cancer Surgery · not yet recruiting
NCT07462351 — System-integrated Point-of-Care Ultrasound in Breast Cancer Screening · NA · recruiting
NCT06975696 — Fusion Imaging in Endovascular Thrombectomy for Acute Ischemic Stroke · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03437538 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Region Skane
Last refreshed: 13 November 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03437538.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing