NCT03437408

Late Potentials and Ablation Index in Ventricular Tachycardia Ablation

Completed NA Last updated 29 September 2021

What this trial tests

NA trial testing Mapping and ablation in Ventricular Tachycardia in 15 participants. Completed in 22 October 2020.

Timeline

26 June 2019

Primary endpoint
22 October 2020

22 October 2020

Quick facts

Lead sponsor	University Hospital Southampton NHS Foundation Trust
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	15
Start date	26 June 2019
Primary completion	22 October 2020
Estimated completion	22 October 2020
Sites	1 location across United Kingdom

Drugs / interventions tested

• Mapping and ablation

Conditions studied

• Ventricular Tachycardia — all drugs for Ventricular Tachycardia →

Sponsor

University Hospital Southampton NHS Foundation Trust

Who can join

Adults 18 to 100, any sex, with Ventricular Tachycardia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

There is an increasing evidence regarding the efficacy of a substrate-based ablation approach to ventricular tachycardia (VT). This approach involves identifying regions of scar and also areas displaying late potentials and fractionated activity. Automated mapping systems are now available which may be able to generate high density maps displaying regions containing both late potentials and ventricular scar. Such an automated approach has not been validated. Furthermore, most patients presenting for VT ablation have pacing devices in situ. It is not known how the pacing modality affect the substrate maps generated for these procedures. Once an area felt to be important to ablate has been identified, the next key step is to perform effective ablation. An algorithm has now been made available (Ablation index - Biosense Webster Inc.,) which in preclinical studies is an effective predictor of radiofrequency lesion depth. This algorithm has been studied extensively in the atrium but not in the ventricle. This study would also seek to collect ablation index data during ablation to assess the algorithm during ventricular ablation.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. The challenge of optimising ablation lesions in catheter ablation of ventricular tachycardia.
   Proietti R, Lichelli L, Lellouche N, Dhanjal T. · · 2021 · cited 11× · PMID 33664896 · DOI 10.1002/joa3.12489
2. Radiofrequency Ablation of the Diseased Human Left Ventricle: Biophysical and Electrogram-Based Analysis.
   Bates AP, Paisey J, Yue A, Banks P, et al · · 2023 · cited 3× · PMID 36371330 · DOI 10.1016/j.jacep.2022.10.001
3. Clinical and Laboratory Predictors of Long-Term Outcomes after Catheter Ablation for a Ventricular Electrical Storm.
   Sławiński G, Hawryszko M, Dyda-Kristowska J, Królak T, et al · · 2024 · cited 1× · PMID 38352195 · DOI 10.1155/2024/5524668