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NCT03433950: CLIN-HTN-PD
Clinical Characteristics of Parkinson's Disease Subjects With Severe Hypertension During Motor OFFs.
trial testing No Intervention in Parkinson Disease in 10 participants. Suspended.
31 December 2022
Quick facts
| Lead sponsor | Oregon Health and Science University |
|---|---|
| Status | Suspended |
| Study type | OBSERVATIONAL |
| Enrollment | 10 |
| Start date | 6 February 2018 |
| Primary completion | 31 December 2022 |
| Estimated completion | 31 December 2022 |
| Sites | 1 location across United States |
Drugs / interventions tested
- No Intervention
Conditions studied
- Parkinson Disease — all drugs for Parkinson Disease →
- Hypertension — all drugs for Hypertension →
- Antiparkinsonism Drugs Causing Adverse Effects in Therapeutic Use — all drugs for Antiparkinsonism Drugs Causing Adverse Effects in Therapeutic Use →
Sponsor
Oregon Health and Science University
Who can join
Adults 18 to 99, any sex, with Parkinson Disease or Hypertension. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Current management of hypertension in PD motor fluctuators is flawed. The current practice often is to treat transient hypertensive spikes reported by patients or measured in clinics with anti-hypertensive medications. This may contribute to morbidity by worsening orthostatic hypotension and increasing fall risk. There is a scarcity of literature on this subject and there is no documentation of severe hypertension with rises in systolic blood pressure exceeding 50% of baseline occurring during motor "OFF". There are two studies that have demonstrated that blood pressure fluctuation can occur in motor fluctuators during the "OFF" state1,2. The study by Baratti et al measured blood pressure in 13 Parkinson's disease patients, 7 with motor fluctuations and 6 without fluctuations. In the fluctuators, the mean systolic/diastolic blood pressures were significantly higher than the non-fluctuators during the "OFF" state but not the "ON" state.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03433950
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03433950 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Oregon Health and Science University
- Last refreshed: 16 November 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03433950.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing