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NCT03432689
Cycloserine rTMS Plasticity Augmentation
Phase 1 trial testing Transcranial Magnetic Stimulation in Motor Activity in 12 participants. Completed in 7 November 2018.
7 November 2018
Quick facts
| Lead sponsor | University of Calgary |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | basic science |
| Enrollment | 12 |
| Start date | 6 August 2018 |
| Primary completion | 7 November 2018 |
| Estimated completion | 7 November 2018 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Transcranial Magnetic Stimulation — full drug profile →
- Cycloserine (CYCLOSERINE) — full drug profile →
- Placebo Oral Tablet — full drug profile →
Conditions studied
- Motor Activity — all drugs for Motor Activity →
Sponsor
University of Calgary
Who can join
Adults 18 to 60, any sex, with Motor Activity. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Transcranial magnetic stimulation (rTMS) is an investigational and therapeutic modality that impacts the connection strength between neurons by delivering patterned energy. In response to this patterned energy neurons fire and adapt by changing their connection strengths. This change in connection strengths is believed to be the underlying mechanism whereby this intervention has therapeutic benefit for this intervention in conditions such as depression. The purpose of this study is to test a means of enhancing the effect of rTMS using a medication (cycloserine) that has been shown to augment and stabilize activity dependent neuronal changes. The investigators wish to use the motor system, where the associated muscle response to brain stimulation can be measured, to probe activity dependent changes in connection strength between neurons.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03432689
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Motor Activity
Currently open trials in the same condition.
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Other University of Calgary trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03432689 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Calgary
- Last refreshed: 9 November 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03432689.
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