NCT03426176 is a NA clinical trial of oxytocin nasal spray in Healthy, sponsored by University of Electronic Science and Technology of China.

Who is sponsoring NCT03426176?

NCT03426176 is sponsored by University of Electronic Science and Technology of China.

What drugs are being tested in NCT03426176?

Interventions in NCT03426176: oxytocin nasal spray, intranasal placebo treatment (placebo-control for oxytocin), ATD treatment, oral placebo treatment (placebo-control for ATD).

Is NCT03426176 still recruiting?

NCT03426176 is currently status unknown. Last updated 8 February 2018.

Last reviewed 2018-02-08 · How we verify

NCT03426176

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Interaction Between Oxytocin and Serotonin

Status unknown NA Last updated 8 February 2018

What this trial tests

NA trial testing oxytocin nasal spray in Healthy in 100 participants. Status unknown.

Timeline

1 February 2018

Primary endpoint
15 June 2019

15 July 2019

Quick facts

Lead sponsor	University of Electronic Science and Technology of China
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	basic science
Enrollment	100
Start date	1 February 2018
Primary completion	15 June 2019
Estimated completion	15 July 2019
Sites	1 location across China

Drugs / interventions tested

oxytocin nasal spray — full drug profile →
intranasal placebo treatment (placebo-control for oxytocin) — full drug profile →
ATD treatment — full drug profile →
oral placebo treatment (placebo-control for ATD) — full drug profile →

Conditions studied

Healthy — all drugs for Healthy →

Sponsor

University of Electronic Science and Technology of China

Who can join

Adults 18 to 30, male only, with Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

the study aims to explore whether there is an interaction between oxytocin and serotonin in the regulation of emotion-based behavior by using a between-subject randomized double blind pharmacological fMRI design during which 4 groups of healthy male subjects will receive combinations of oxytocin nasal-spray (versus placebo) and acute tryptophan depletion (ATD, versus placebo)

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Oxytocinergic Modulation of Stress-Associated Amygdala-Hippocampus Pathways in Humans Is Mediated by Serotonergic Mechanisms.
Lan C, Liu C, Li K, Zhao Z, et al · · 2022 · cited 16× · PMID 35723242 · DOI 10.1093/ijnp/pyac037
Oxytocinergic modulation of threat-specific amygdala sensitization in humans is critically mediated by serotonergic mechanisms
Liu C, Lan C, Li K, Zhou F, et al · · 2020 · cited 1× · DOI 10.1101/2020.05.20.105684

Verify or expand the search:

Other trials of oxytocin nasal spray

Trials testing the same drug.

NCT06945926 — The Effect of Oxytocin Nasal Spray on Preventing Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surger · Phase 2 · not yet recruiting
NCT03577457 — The Interaction Between Oxytocin and Serotonin · NA · unknown
NCT03043053 — The Effects of Oxytocin in Obese Adults · Phase 2 · completed

Other recruiting trials for Healthy

Currently open trials in the same condition.

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NCT07496697 — Effects of Electroacupuncture at NP82 and SP15 on Bowel Motility in Healthy Subjects · NA · recruiting
NCT06431932 — Pilot Trial of Fisetin in Healthy Volunteers and Older Patients With Multimorbidity · Phase 1, PHASE2 · recruiting

Other University of Electronic Science and Technology of China trials

Trials by the same sponsor.

NCT07416370 — Neurofeedback Training of Anterior Insula Activity Based on Unidimensional vs. Multidimensional Interoceptive Regulation · NA · enrolling by invitation
NCT07389486 — Continuous vs. Intermittent Rt-fMRI Neurofeedback Training of the Anterior Insula · NA · recruiting
NCT07425938 — Oxytocin's Effects on Emotional Processing and Its Acting Routes · NA · recruiting
NCT07364084 — Real-time Neurofeedback Training of the Medial Prefrontal Cortex Based on Imagined Social Support · NA · recruiting
NCT07367672 — The Power of Belief: Expectation-driven and Placebo Modulation of Empathic Pain · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03426176 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Electronic Science and Technology of China
Last refreshed: 8 February 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03426176.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing