NCT03425084 is a Phase 1 clinical trial of Morphine in Organic Cation Transporter 1, sponsored by University of Southern Denmark.

Who is sponsoring NCT03425084?

NCT03425084 is sponsored by University of Southern Denmark.

What drugs are being tested in NCT03425084?

Interventions in NCT03425084: Morphine.

What condition does NCT03425084 study?

NCT03425084 studies Organic Cation Transporter 1, Morphine.

Is NCT03425084 still recruiting?

NCT03425084 is currently completed. Last updated 29 June 2020.

Last reviewed 2020-06-29 · How we verify

NCT03425084

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Genetic Variation in Organic Cation Transport 1 (OCT1) and Its Significance for Morphine Pharmacokinetics

Completed Phase 1 Last updated 29 June 2020

What this trial tests

Phase 1 trial testing Morphine in Organic Cation Transporter 1 in 86 participants. Completed in 7 February 2020.

Timeline

1 June 2018

Primary endpoint
7 February 2020

7 February 2020

Quick facts

Lead sponsor	University of Southern Denmark
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	other
Enrollment	86
Start date	1 June 2018
Primary completion	7 February 2020
Estimated completion	7 February 2020
Sites	2 locations across Denmark

Drugs / interventions tested

Morphine

Conditions studied

Organic Cation Transporter 1 — all drugs for Organic Cation Transporter 1 →
Morphine — all drugs for Morphine →

Sponsor

University of Southern Denmark

Who can join

Adults 18 to 90, any sex, with Organic Cation Transporter 1 or Morphine. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The main objective of the trial is to investigate the effect of known genetic variants in organic cation transporter 1 (OCT1) on the effect of morphine after major surgery

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients.
Kuhlmann I, Hjelmar Petersen R, Overgaard M, Dornonville de la Cour K, et al · · 2022 · cited 5× · PMID 34599645 · DOI 10.1111/bcpt.13667

Verify or expand the search:

Other trials of Morphine

Trials testing the same drug.

NCT06315920 — Analgesic Effect of Parecoxib Versus Morphine in SCD Patients Presenting to the Emergency Department · Phase 3 · not yet recruiting
NCT07491146 — Phase II Clinical Study of the Efficacy and Safety of HSK55718 in the Treatment of Abdominal Postoperative Pain · Phase 2 · not yet recruiting
NCT07412223 — Effect of Tegileridine on Postoperative Bowel Function Recovery in Abdominal Surgery · Phase 4 · not yet recruiting
NCT07246785 — Anrikefon-based Patient-controlled Intravenous Analgesia After Laparoscopic Surgery · Phase 4 · terminated
NCT07201272 — Transversalis Fascia Plane Block Versus Intrathecal Morphine for Postoperative Analgesia in Total Abdominal Hysterectomy · NA · recruiting

Other University of Southern Denmark trials

Trials by the same sponsor.

NCT07531290 — PeerScreen Trial - Reducing Screen Media Use in Peer-groups of Young People · NA · not yet recruiting
NCT07384273 — Evaluating the Effectiveness of an Internet-based Therapy (iCARE) to Treat Symptoms of Postpartum Depression · NA · recruiting
NCT07426679 — Should Anaesthesiologists Be Taught to Perform Ultrasound-- Assisted Neuraxial Access in Spinal Anaesthesia? · NA · recruiting
NCT07104292 — Pelvic Floor Muscle Training During Pregnancy · NA · recruiting
NCT07194759 — Health Literacy Levels of Patients Living With Type 2 Diabetes and Multi-disease and Their Families Using HLQTM · enrolling by invitation

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03425084 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Southern Denmark
Last refreshed: 29 June 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03425084.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing