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NCT03422731
Multi-modality Imaging and Collection of Biospecimen Samples in Understanding Bone Marrow Changes in Patients With Acute Myeloid Leukemia Undergoing TBI and Chemotherapy
EARLY_PHASE1 trial testing Biospecimen Collection in Acute Lymphoblastic Leukemia in 74 participants. Currently enrolling.
6 November 2026
Quick facts
| Lead sponsor | City of Hope Medical Center |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 74 |
| Start date | 15 February 2018 |
| Primary completion | 6 November 2026 |
| Estimated completion | 6 November 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Biospecimen Collection — full drug profile →
- Dual-Energy Computed Tomography
- Fluorothymidine F-18
- Laboratory Biomarker Analysis — full drug profile →
- Magnetic Resonance Imaging
- Positron Emission Tomography
Conditions studied
- Acute Lymphoblastic Leukemia — all drugs for Acute Lymphoblastic Leukemia →
- Acute Myeloid Leukemia — all drugs for Acute Myeloid Leukemia →
Sponsor
City of Hope Medical Center
Who can join
18 and older, any sex, with Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This clinical trial investigates multi-modality imaging and collection of biospecimen samples in understanding bone marrow changes in patients with acute myeloid leukemia undergoing total body irradiation (TBI) and chemotherapy. Using multi-modality imaging and collecting biospecimen samples may help doctors know more about how TBI and chemotherapy can change the bone marrow.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Applications of PET in Diagnosis and Prognosis of Leukemia.
Zhao Z, Hu Y, Li J, Zhou Y, et al · · 2020 · cited 17× · PMID 32875963 · DOI 10.1177/1533033820956993 -
Proton Density Fat Fraction Micro-MRI for Non-Invasive Quantification of Bone Marrow Aging and Radiation Effects in Mice.
Ghimire H, Malekzadeh M, Lim JE, Madabushi SS, et al · · 2025 · cited 1× · PMID 40281709 · DOI 10.3390/bioengineering12040349 -
AI-Driven Bone and Marrow Segmentation on FLT-PET/CT: Technical Multi-organ Validation in AML and HCT
Malekzadeh M, Ghimire H, Popuri K, Fujita K, et al · · 2026 · DOI 10.21203/rs.3.rs-9077609/v1
Verify or expand the search:
- PubMed search for NCT03422731
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other City of Hope Medical Center trials
Trials by the same sponsor.
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- NCT07218692 — RP2 and Tivozanib for the Treatment of Metastatic Renal Cell Cancer After Progression on Immunotherapy · Phase 2 · not yet recruiting
- NCT07363408 — Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment · Phase 1 · not yet recruiting
- NCT07226102 — Virtual Mental Health Intervention to Address Fear of Progression for Women With High Risk or Stage III-IV Gynecologic o · NA · withdrawn
- NCT07225855 — Geriatric Assessment and Management for Older Adults Undergoing Chemotherapy and Radiation Therapy for Head and Neck Can · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03422731 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by City of Hope Medical Center
- Last refreshed: 15 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03422731.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing