NCT03418428 (DiGMA) is a clinical trial in Gastric Cancer, sponsored by Vilnius University.

Who is sponsoring NCT03418428?

NCT03418428 is sponsored by Vilnius University.

What condition does NCT03418428 study?

NCT03418428 studies Gastric Cancer.

Is NCT03418428 still recruiting?

NCT03418428 is currently completed. Last updated 2 January 2020.

Last reviewed 2020-01-02 · How we verify

NCT03418428: DiGMA

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Intestinal Microbiome After Gastrectomy

Completed Last updated 2 January 2020

What this trial tests

trial in Gastric Cancer in 34 participants. Completed in 1 December 2019.

Timeline

1 April 2018

Primary endpoint
30 June 2019

1 December 2019

Quick facts

Lead sponsor	Vilnius University
Status	Completed
Study type	OBSERVATIONAL
Enrollment	34
Start date	1 April 2018
Primary completion	30 June 2019
Estimated completion	1 December 2019
Sites	1 location across Lithuania

Conditions studied

Gastric Cancer — all drugs for Gastric Cancer →

Sponsor

Vilnius University

Who can join

18 and older, any sex, with Gastric Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The gastric barrier plays a major role in the maintanance of the distal intestinal microbiome composition. It has been shown before that the use of gastric acid suppression medication, such as proton pump inhibitors, are associated with distinctive alterations of the intestinal microbiome. Foremost, the invasion of predominantly oral bacteria, like Veillonella and Streptococcus species, were a resurring finding in previous reports. Gastric cancer treatment includes the total or subtotal resection of the stomach which can influence the gastric acid production. However, the influence by alterations in gastric milieu after this treatment on the composition of the intestinal microbiome is not well studied. Therefore, the intestinal microbiome of patients after total or subtotal gastrectomy and its influence on intestinal inflammation and gut permeability will be studied.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Distal Gastrectomy with Billroth II Reconstruction is Associated with Oralization of Gut Microbiome and Intestinal Inflammation: A Proof-of-Concept Study.
Horvath A, Bausys A, Sabaliauskaite R, Stratilatovas E, et al · · 2021 · cited 23× · PMID 32504369 · DOI 10.1245/s10434-020-08678-1
Emulating interactions between microorganisms and tumor microenvironment to develop cancer theranostics.
Jiang T, Yang T, Chen Y, Miao Y, et al · · 2022 · cited 18× · PMID 35401838 · DOI 10.7150/thno.70719
Effects of intratumoral microbiota on tumorigenesis, anti-tumor immunity, and microbe-based cancer therapy.
Zheng J, Chen H. · · 2024 · cited 6× · PMID 39391251 · DOI 10.3389/fonc.2024.1429722

Verify or expand the search:

Other recruiting trials for Gastric Cancer

Currently open trials in the same condition.

NCT07525765 — AI-assisted Decision-making of Reoperation for Postoperative Bleeding of Gastric Cancer · recruiting
NCT07464470 — Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Gastroesophageal Cancers · recruiting
NCT07432633 — [18F]FPyQCP PET Imaging of Fibroblast Activation Protein in Selected Oncology Indications · Phase 1, PHASE2 · recruiting
NCT07431281 — Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Meta · Phase 3 · recruiting
NCT07448493 — Local Treatment Strategies for Brain Metastases of Gastric and Esophageal Cancer · active not recruiting

Other Vilnius University trials

Trials by the same sponsor.

NCT06966752 — Comparison of Continuous Positive Airway Pressure (CPAP) and Non-Invasive Positive Pressure Ventilation (NIPPV) in Prete · NA · recruiting
NCT07024901 — The Effects of the Somatic Intervention 'Dance-Walk' on Body Awareness, Vitality, and Mental Health in Help-Seeking Adul · NA · completed
NCT06651411 — The Feasibility of Chatbot-based Stress Management Intervention STARS for Youth in Lithuania · NA · active not recruiting
NCT06475716 — Guided Internet-based Trauma-focused CBT Programme for Post-traumatic Stress Disorder 'Spring' · NA · not yet recruiting
NCT06502704 — Bile Acids and Microbiome in Early Colorectal Carcinogenesis · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03418428 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Vilnius University
Last refreshed: 2 January 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03418428.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing