NCT03417648

A Nutrition Intervention for Arthritis -3 (WCCR-ARTH3)

Completed NA Last updated 4 March 2019

What this trial tests

NA trial testing Plant-based diet in Rheumatoid Arthritis in 8 participants. Completed in 14 December 2018.

Timeline

8 March 2018

Primary endpoint
14 December 2018

14 December 2018

Quick facts

Lead sponsor	Physicians Committee for Responsible Medicine
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	supportive care
Enrollment	8
Start date	8 March 2018
Primary completion	14 December 2018
Estimated completion	14 December 2018
Sites	1 location across United States

Drugs / interventions tested

• Plant-based diet
• Supplement

Conditions studied

• Rheumatoid Arthritis — all drugs for Rheumatoid Arthritis →

Sponsor

Physicians Committee for Responsible Medicine

Who can join

Adults 18 to 90, any sex, with Rheumatoid Arthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of the study is to assess whether, in individuals with rheumatoid arthritis, a low-fat, vegan diet improves pain and other subjective symptoms more effectively than a control supplement or a placebo. The principal measure is pain as measured by Visual Analog Scale (VAS) and disease activity as measured by number of painful swollen and tender joints, respectively. The study duration is 36 weeks.

This study tests that a low fat, plant-based (vegan) diet free of foods commonly identified as triggers improves mood, using the Center for Epidemiologic Studies Depression Scale-Revised (CESD-R), and the Beck Depression Inventory II (BDI-II).

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Effect of Anti-Inflammatory Diets on Pain in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.
   Schönenberger KA, Schüpfer AC, Gloy VL, Hasler P, et al · · 2021 · cited 88× · PMID 34959772 · DOI 10.3390/nu13124221
2. A Randomized, Crossover Trial of a Nutritional Intervention for Rheumatoid Arthritis.
   Barnard ND, Levin S, Crosby L, Flores R, et al · · 2025 · cited 1× · PMID 39981557 · DOI 10.1177/15598276221081819