NCT03416738

Modeling Treated Recovery From Aphasia

Completed NA Last updated 28 April 2022

What this trial tests

NA trial testing Semantically focused treatment in Aphasia in 127 participants. Completed in 30 May 2021.

Timeline

2 August 2016

Primary endpoint
30 May 2021

30 May 2021

Quick facts

Lead sponsor	University of South Carolina
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	treatment
Enrollment	127
Start date	2 August 2016
Primary completion	30 May 2021
Estimated completion	30 May 2021
Sites	2 locations across United States

Drugs / interventions tested

• Semantically focused treatment
• Phonologically focused treatment

Conditions studied

• Aphasia — all drugs for Aphasia →
• Stroke — all drugs for Stroke →
• Stroke, Ischemic — all drugs for Stroke, Ischemic →
• Aphasia, Broca — all drugs for Aphasia, Broca →

Sponsor

University of South Carolina

Who can join

Adults 21 to 80, any sex, with Aphasia or Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Stroke is the leading cause of adult disability in the United States, and aphasia is common following a stroke to the left hemisphere of the brain. Aphasia therapy can improve aphasia recover; however, very little is known about how different patients respond to different types of treatments.

The purpose of this study is to understand how the following factors influence an individual's response to aphasia treatment: 1) biographical factors (e.g., age, education, gender), 2) post-stroke cognitive/linguistic abilities and learning potential, and 3) the location and extent of post-stroke brain damage. We are also interested in understanding the kinds of treatment materials that should be emphasized in speech/language treatment.

Overall, the goal of the current research is to inform the clinical management of post-stroke aphasia by identifying factors that can predict how an individual will respond to different treatment methods.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

1. Advanced Brain Age and Chronic Poststroke Aphasia Severity.
   Busby N, Wilmskoetter J, Gleichgerrcht E, Rorden C, et al · · 2023 · cited 26× · PMID 36526425 · DOI 10.1212/wnl.0000000000201693
2. Predicting Outcomes of Language Rehabilitation: Prognostic Factors for Immediate and Long-Term Outcomes After Aphasia Therapy.
   Kristinsson S, Basilakos A, den Ouden DB, Cassarly C, et al · · 2023 · cited 20× · PMID 36827514 · DOI 10.1044/2022_jslhr-22-00347
3. Verbal working memory and syntactic comprehension segregate into the dorsal and ventral streams, respectively.
   Matchin W, Mollasaraei ZK, Bonilha L, Rorden C, et al · · 2024 · cited 2× · PMID 39713237 · DOI 10.1093/braincomms/fcae449
4. Partial least squares multimodal analysis of brain network correlates of language deficits in aphasia.
   Kristinsson S, den Ouden DB, Rorden C, Newman-Norlund R, et al · · 2025 · cited 1× · PMID 40672938 · DOI 10.1093/braincomms/fcaf246
5. Dissociating reading and auditory comprehension in persons with aphasia.
   Harrington RM, Kristinsson S, Wilmskoetter J, Busby N, et al · · 2024 · cited 1× · PMID 38585671 · DOI 10.1093/braincomms/fcae102
6. Naming practice effects and inconsistencies relate to treatment outcome in people with aphasia.
   Wilmskoetter J, Blackwood K, Kristinsson S, Walker G, et al · · 2025 · PMID 40953813 · DOI 10.1016/j.neuropsychologia.2025.109271
7. Advanced brain aging mediates the relationship between cardiovascular health and aphasia severity in chronic stroke.
   Busby N, Rangus I, Riccardi N, Newman-Norlund R, et al · · 2025 · PMID 40896171 · DOI 10.1016/j.nbas.2025.100150