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NCT03415685

Lutronic PicoPlus Exploratory Clinical Trial

Terminated NA Results posted Last updated 20 December 2023
What this trial tests

NA trial testing PicoPlus laser system in Tattoo; Pigmentation in 39 participants. Terminated before completion.

Timeline
12 October 2017
Primary endpoint
6 September 2018
3 October 2018

Quick facts

Lead sponsorCynosureLutronic
PhaseNA
StatusTerminated
Study typeINTERVENTIONAL
Allocationnon randomized
Designparallel
Maskingnone
Primary purposetreatment
Enrollment39
Start date12 October 2017
Primary completion6 September 2018
Estimated completion3 October 2018
Sites4 locations across United States

Drugs / interventions tested

Conditions studied

Sponsor

CynosureLutronic — full company profile →

Who can join

Adults 18 to 60, any sex, with Tattoo; Pigmentation or Melasma. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Investigator's Global Assessment of Improvement Primary · Up to 6 Months following final study treatment

Overall aesthetic improvement based on completion of the Physician's Global Assessment of Improvement Scale. Physician evaluators will review study photos post-final treatment, and rate the degree of tattoo clearing or reduction in benign pigmentation observed in the subject's treated area using the following definitions: 3 = Very significant or complete clearing (75-100%) 2 = Significant clearing (50-74%) 1 = Moderate clearing (25-49%) 0 = Mild or no clearing (0-24%)

GroupValue95% CI
Group A: PicoPlus for Unwanted Tattoos.1
Group B: PicoPlus for Other Dermatological Conditions6
Group A: PicoPlus for Unwanted Tattoos.2
Group B: PicoPlus for Other Dermatological Conditions0
Group A: PicoPlus for Unwanted Tattoos.3
Group B: PicoPlus for Other Dermatological Conditions2
Group A: PicoPlus for Unwanted Tattoos.0
Group B: PicoPlus for Other Dermatological Conditions0
Subject's Global Assessment of Improvement Secondary · 1 month, 3 Months, 6 Months (Group A Only) post final treatment

Overall aesthetic improvement based on completion of the Subject's Global Assessment of Improvement Scale. Subjects will be asked review study photos post-final treatment, and rate the degree of tattoo clearing or reduction in benign pigmentation observed in the subject's treated area using the following definitions: 3 = Very significant or complete clearing (75-100%) 2 = Significant clearing (50-74%) 1 = Moderate clearing (25-49%) 0 = Mild or no clearing (0-24%)

GroupValue95% CI
Group A: PicoPlus for Unwanted Tattoos.0
Group B: PicoPlus for Other Dermatological Conditions6
Group A: PicoPlus for Unwanted Tattoos.3
Group B: PicoPlus for Other Dermatological Conditions3
Group A: PicoPlus for Unwanted Tattoos.3
Group B: PicoPlus for Other Dermatological Conditions0
Group A: PicoPlus for Unwanted Tattoos.0
Group B: PicoPlus for Other Dermatological Conditions0

Adverse events — posted to ClinicalTrials.gov

Time frame: Adverse events were collected up to 6 months post final treatment.. Reporting threshold: 0%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

Group A: PicoPlus for Unwanted Tattoos.
Serious: 0/11 (0%)
Deaths: 0/11
Group B: PicoPlus for Other Dermatological Conditions
Serious: 0/28 (0%)
Deaths: 0/28
Other adverse events (17 terms — click to expand)

ReactionSystemGroup A: PicoPlus for Unwa…Group B: PicoPlus for Othe…
ErythemaSkin and subcutaneous tissue disorders
EdemaSkin and subcutaneous tissue disorders
Itching/PruritisSkin and subcutaneous tissue disorders
Scabbing/PeelingSkin and subcutaneous tissue disorders
Darkening of LesionsSkin and subcutaneous tissue disorders
Hypo/Hyper-PigmentationSkin and subcutaneous tissue disorders
Blisters/Scabs/CrustingSkin and subcutaneous tissue disorders
Bruising/EcchymosisSkin and subcutaneous tissue disorders
Bleeding of InkSkin and subcutaneous tissue disorders
Treatment DiscomfortSkin and subcutaneous tissue disorders
DrynessSkin and subcutaneous tissue disorders
Heat SensationSkin and subcutaneous tissue disorders
Skin BumpsSkin and subcutaneous tissue disorders
PurpuraSkin and subcutaneous tissue disorders
RoughnessSkin and subcutaneous tissue disorders
TightnessSkin and subcutaneous tissue disorders
Welting/Raised Area of EdemaSkin and subcutaneous tissue disorders

Data from ClinicalTrials.gov NCT03415685 adverse events section.

Sponsor's own description

This study will evaluate the use of the Lutronic PicoPlus for treatment of dermatological conditions such as unwanted tattoos and benign pigmented lesions.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Tattoo; Pigmentation

Currently open trials in the same condition.

Other CynosureLutronic trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03415685.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing