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NCT03415191
The Pre-Emptive Administration Of Ketamine for Controlling Post-thoracotomy Pain
NA trial testing Ketamine in Post Thoracotomy Pain in 75 participants. Completed in 1 February 2015.
21 December 2014
Quick facts
| Lead sponsor | University of Campania Luigi Vanvitelli |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 75 |
| Start date | 5 January 2012 |
| Primary completion | 21 December 2014 |
| Estimated completion | 1 February 2015 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Ketamine (ketamine) — full drug profile →
- Normal Saline
Conditions studied
- Post Thoracotomy Pain — all drugs for Post Thoracotomy Pain →
Sponsor
University of Campania Luigi Vanvitelli
Who can join
18 and older, any sex, with Post Thoracotomy Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this paper is to evaluate whether the pre-emptive administration of Ketamine would potentiate the effect of intravenous morphine analgesia in management of post thoracotomy pain. This was a single center, double-blind, placebo controlled, parallel-group, prospective study. Patients were randomly assigned to receive 1 mg/kg ketamine (Ketamine Group) or an equivalent dose of normal saline (Placebo Group) before thoracotomy in 1:1 ratio. All patients received postoperatively intravenous morphine administration as additional analgesic regimen Primary end-point was pain relief measured with Visual Analogue Scale at rest. The secondary end-points were the reduction of inflammatory response expressed by plasma c-reactive protein levels, the morphine consumption, and the rate of side effects. The measurements were carried out 6; 12; 24; 36; and 48 post operative hours.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03415191
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03415191 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Campania Luigi Vanvitelli
- Last refreshed: 30 January 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03415191.
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