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NCT03414112
The Impact of Oxytocin on the Neurobiology of Anorexia Nervosa
EARLY_PHASE1 trial testing Intranasal oxytocin in Anorexia Nervosa in 16 participants. Completed in 30 April 2021.
30 April 2021
Quick facts
| Lead sponsor | University of Minnesota |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | other |
| Enrollment | 16 |
| Start date | 25 September 2018 |
| Primary completion | 30 April 2021 |
| Estimated completion | 30 April 2021 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Intranasal oxytocin — full drug profile →
Conditions studied
- Anorexia Nervosa — all drugs for Anorexia Nervosa →
Sponsor
University of Minnesota
Who can join
18 and older, female only, with Anorexia Nervosa. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will use a randomized, controlled, double-blind design involving the administration of intranasal oxytocin (INOT) or placebo to adults with anorexia nervosa, restricting subtype and age-matched controls prior to neuroimaging to assess the impact on frontolimbic brain activity in response to socioemotional stimuli as well as eating behavior in a test meal paradigm.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Nose-to-Brain Delivery of Therapeutic Peptides as Nasal Aerosols.
Alabsi W, Eedara BB, Encinas-Basurto D, Polt R, et al · · 2022 · cited 44× · PMID 36145618 · DOI 10.3390/pharmaceutics14091870 -
Pituitary crosstalk with bone, adipose tissue and brain.
Zaidi M, Yuen T, Kim SM. · · 2023 · cited 31× · PMID 37715028 · DOI 10.1038/s41574-023-00894-5
Verify or expand the search:
- PubMed search for NCT03414112
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Intranasal oxytocin
Trials testing the same drug.
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- NCT06405737 — Oxytocin's Effect on the Advantageous- and Disadvantageous-inequity · NA · completed
- NCT05312008 — Does Oxytocin Alter Tolerance to or Motivation for Alcohol · Phase 2 · terminated
- NCT05265806 — The Effects of Oxytocin Treatment on Social Touch · NA · completed
- NCT05245708 — Effects of Oxytocin on Reinforcement Learning and Interoception · NA · completed
Other recruiting trials for Anorexia Nervosa
Currently open trials in the same condition.
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Other University of Minnesota trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03414112 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Minnesota
- Last refreshed: 11 February 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03414112.
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