Predicting Fluid Responsiveness Using Transiently Increased Intrathoracic Pressure in Mechanically Ventilated Patients

NCT03413657 NA COMPLETED

The goal of this study is to identify in patients requiring active fluid resuscitation and mechanical ventilation for circulatory shock, can a controlled increase in intrathoracic pressure (either by positive-end expiratory pressure (PEEP) or tidal volume (TV)) predict responsiveness to additional fluid resuscitation. We hypothesize that a temporary, physiologically-safe increase in positive-end expiratory pressure (PEEP) and/or a temporary increase in tidal volume (from 6 cc/kg predicted body weight (PBW) to 8 cc/kg PBW) in patients requiring invasive mechanical ventilation will predict fluid responsiveness based upon an assessment of the change in pulse pressure and stroke volume variation.

Details

Lead sponsor	University of California, Davis
Phase	NA
Status	COMPLETED
Enrolment	5
Start date	Wed Dec 27 2017 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Thu Sep 13 2018 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Fluid Reponsiveness

Interventions

• Increase in intrathoracic pressure

Countries

United States