NCT03413423

Post Acute Cardiac Event Smoking (PACES) Study

Active, enrolled NA Last updated 15 September 2025

What this trial tests

NA trial testing BAT-CS in Acute Coronary Syndrome in 233 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

29 January 2018

Primary endpoint
8 May 2024

30 May 2026

Quick facts

Lead sponsor	Hennepin Healthcare Research Institute
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	233
Start date	29 January 2018
Primary completion	8 May 2024
Estimated completion	30 May 2026
Sites	1 location across United States

Drugs / interventions tested

• BAT-CS
• Smoking Cessation and Health & Wellness

Conditions studied

• Acute Coronary Syndrome — all drugs for Acute Coronary Syndrome →
• Tobacco Use — all drugs for Tobacco Use →

Sponsor

Hennepin Healthcare Research Institute

Who can join

Adults 18 to 75, any sex, with Acute Coronary Syndrome or Tobacco Use. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Summary of the Project :

Quitting smoking following acute coronary syndrome (ACS) can reduce mortality up to 50%. However, depression and smoking are highly co-morbid and depressed mood may interfere with cessation and independently predicts mortality. Thus, a single, integrated treatment for both smoking and depression could be highly effective in reducing post-acute coronary syndrome mortality. Behavioral Activation (BA) is a well established treatment for depression and has recently shown promise as a treatment for smoking cessation. The investigators systematically developed an intervention integrating gold standard smoking cessation counseling with existing BA based mood management techniques for post-ACS smokers; Behavioral Activation Treatment for Cardiac Smokers (BAT-CS).

Objective: For this R01 the investigators will evaluate the efficacy of using a single, integrated treatment that targets both depressed mood and smoking (BAT-CS).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Integrated smoking cessation and mood management following acute coronary syndrome: Protocol for the post-acute cardiac event smoking (PACES) trial.
   Adkins-Hempel M, Japuntich SJ, Chrastek M, Dunsiger S, et al · · 2023 · cited 4× · PMID 37173792 · DOI 10.1186/s13722-023-00388-9