NCT03413202 (EBCAS) is a Phase 4 clinical trial of butylphthalide(NBP) in Acute Ischemic Stroke, sponsored by Yi Yang.

Who is sponsoring NCT03413202?

NCT03413202 is sponsored by Yi Yang.

What drugs are being tested in NCT03413202?

Interventions in NCT03413202: butylphthalide(NBP), placebo.

What condition does NCT03413202 study?

NCT03413202 studies Acute Ischemic Stroke.

Is NCT03413202 still recruiting?

NCT03413202 is currently completed. Last updated 30 June 2022.

Last reviewed 2022-06-30 · How we verify

NCT03413202: EBCAS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effectiveness of Butylphthalide on Dynamic Cerebral Autoregulation in Patients With Acute Ischemic Stroke.

Completed Phase 4 Last updated 30 June 2022

What this trial tests

Phase 4 trial testing butylphthalide(NBP) in Acute Ischemic Stroke in 99 participants. Completed in 25 May 2022.

Timeline

28 February 2018

Primary endpoint
25 March 2022

25 May 2022

Quick facts

Lead sponsor	Yi Yang
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	99
Start date	28 February 2018
Primary completion	25 March 2022
Estimated completion	25 May 2022
Sites	1 location across China

Drugs / interventions tested

butylphthalide(NBP) — full drug profile →
placebo

Conditions studied

Acute Ischemic Stroke — all drugs for Acute Ischemic Stroke →

Sponsor

Yi Yang — full company profile →

Who can join

Adults 18 to 80, any sex, with Acute Ischemic Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a randomized, triple-blind, placebo-controlled, multicenter clinical trial. Eligible patients will be randomized into either the butylphthalide (NBP) or placebo group in a 2:1 ratio.The main purpose of this study is to determine whether butylphthalide can improve dynamic Cerebral Autoregulation (dCA) in large-artery atherosclerosis acute ischemic stroke.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Effectiveness of butylphthalide on cerebral autoregulation in ischemic stroke patients with large artery atherosclerosis (EBCAS study): A randomized, controlled, multicenter trial.
Guo ZN, Yue BH, Fan L, Liu J, et al · · 2023 · cited 10× · PMID 37021629 · DOI 10.1177/0271678x231168507
Unraveling the meta-hallmarks between senescent and tumor cells: A new perspective for senolytic drug discovery.
Liu W, Fan B, Fang T, Li H, et al · · 2025 · cited 1× · PMID 41132829 · DOI 10.1016/j.apsb.2025.08.010

Verify or expand the search:

Other recruiting trials for Acute Ischemic Stroke

Currently open trials in the same condition.

NCT07115940 — Medical Management With Endovascular Thrombectomy Versus Medical Management Alone in Patients Presenting Beyond 24 Hours · NA · recruiting
NCT07404852 — Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemi · NA · recruiting
NCT07361302 — A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Pe · Phase 3 · recruiting
NCT07436156 — SUMMIT RISE Study of Acute Ischemic Stroke Patients · Phase 4 · recruiting
NCT07203625 — Tenecteplase Before Interhospital Transfer in Acute Basilar Artery Occlusion at 4.5 to 24 Hours · Phase 4 · recruiting

Other Yi Yang trials

Trials by the same sponsor.

NCT03484936 — Safety and Efficacy of Remote Ischemic Conditioning in Patients With Spontaneous Intracerebral Hemorrhage · NA · not yet recruiting
NCT07042490 — Efficacy and Safety of Plasma Adsorption Combined With EVT for AIS-LVO · NA · not yet recruiting
NCT03669653 — Safety and Efficacy of Remote Ischemic Conditioning in Patients With Acute Ischemic Stroke · NA · not yet recruiting
NCT05743101 — Safety and Efficacy Study of Levofloxacin Combined With Endovascular Thrombectomy for Acute Ischemic Stroke · NA · not yet recruiting
NCT06941961 — iTBS for Acute Ischemic Stroke After Thrombectomy · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03413202 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Yi Yang
Last refreshed: 30 June 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03413202.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing