Last reviewed · How we verify
NCT03412240: REVRAMP
Reverse RAMP Pacing to Terminate Ventricular Tachycardia ( REV-RAMP)
NA trial testing Induced pacing of the heart in Arrythmia in 25 participants. Status unknown.
10 March 2020
Quick facts
| Lead sponsor | The Leeds Teaching Hospitals NHS Trust |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 25 |
| Start date | 14 December 2017 |
| Primary completion | 10 March 2020 |
| Estimated completion | 10 March 2020 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Induced pacing of the heart
Conditions studied
- Arrythmia — all drugs for Arrythmia →
Sponsor
The Leeds Teaching Hospitals NHS Trust
Who can join
Adults 18 to 90, any sex, with Arrythmia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Cardiac pacing which involved stimulating the heart electrically with electrical wires that go into the heart is routine practice in the diagnosis and treatment of heart rhythm problems. Clinically this involved the fields of cardiac pacing and electrophysiology. Patients who are at risk of sudden death because of serious heart rhythms that are a result of malfunction of the electrical system of the pumping chambers of the heart (ventricles) are generally implanted with specialised pacemakers that can defibrillate (shock) the heart if a nasty life threatening rhythm should result. Shocks are painful and in order to try and treat these rhythms without shocks, anti tachycardia pacing is performed (this is routine part of the device), which aims to interrupt the rhythm by stimulating the heart electrically. This does not always work and can destabilise the rhythm leading to a shock. REVRAMP is a novel modification of anti tachycardia pacing which involved stimulating the heart through the defibrillator wires in a different way. It appears to work better and seems less likely to destabilise the heart rhythm, hence can reduce painful shocks.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Reverse RAMP (REVRAMP) pacing: A novel anti tachycardia pacing technique.
Tayebjee MH, Bowes R, Stegemann B, Holden AV. · · 2022 · PMID 34775047 · DOI 10.1016/j.ipej.2021.11.001
Verify or expand the search:
- PubMed search for NCT03412240
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03412240 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The Leeds Teaching Hospitals NHS Trust
- Last refreshed: 19 February 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03412240.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing