Who is sponsoring NCT03408691?

NCT03408691 is sponsored by Universitaire Ziekenhuizen KU Leuven.

What condition does NCT03408691 study?

NCT03408691 studies Permeability; Increased.

Is NCT03408691 still recruiting?

NCT03408691 is currently completed. Last updated 4 June 2019.

Last reviewed 2019-06-04 · How we verify

NCT03408691: ProSPer

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

PRObiotic and Stress-related PERmeability

Completed NA Last updated 4 June 2019

What this trial tests

NA trial testing Fresh fermented dairy drink containing probiotic strain in Permeability; Increased in 117 participants. Completed in 31 March 2019.

Timeline

23 January 2018

Primary endpoint
22 March 2019

31 March 2019

Quick facts

Lead sponsor	Universitaire Ziekenhuizen KU Leuven
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	117
Start date	23 January 2018
Primary completion	22 March 2019
Estimated completion	31 March 2019
Sites	1 location across Belgium

Drugs / interventions tested

Fresh fermented dairy drink containing probiotic strain
Acidified dairy drink without ferment

Conditions studied

Permeability; Increased — all drugs for Permeability; Increased →

Sponsor

Universitaire Ziekenhuizen KU Leuven — full company profile →

Who can join

Adults 20 to 30, any sex, with Permeability; Increased. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a single-site exploratory study aiming to demonstrate the effect of a fresh fermented dairy drink containing a probiotic strain on stress-related intestinal hyperpermeability in students defending a bachelor's or master's thesis in front of a jury at the University of Leuven (Belgium).

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

<i>Lactobacillus rhamnosus</i> CNCM I-3690 decreases subjective academic stress in healthy adults: a randomized placebo-controlled trial.
Wauters L, Van Oudenhove L, Accarie A, Geboers K, et al · · 2022 · cited 25× · PMID 35130109 · DOI 10.1080/19490976.2022.2031695
Does the Gut Microbial Metabolome Really Matter? The Connection between GUT Metabolome and Neurological Disorders.
Marć MA, Jastrząb R, Mytych J. · · 2022 · cited 18× · PMID 36235622 · DOI 10.3390/nu14193967
Probiotic-mediated modulation of gut microbiome in students exposed to academic stress: a randomized controlled trial.
Vázquez-Castellanos JF, Maciel LF, Wauters L, Gregory A, et al · · 2025 · PMID 40691449 · DOI 10.1038/s41522-025-00776-w

Verify or expand the search:

Other recruiting trials for Permeability; Increased

Currently open trials in the same condition.

NCT05477212 — Evaluation of Gut Permeability in Patients Affected by Obesity and NAFLD: Influence of Ketogenic Diet. · NA · recruiting
NCT04565821 — Feasibility Study to Assess a Trans-nasal Intestinal Potential Difference Probe · NA · active not recruiting

Other Universitaire Ziekenhuizen KU Leuven trials

Trials by the same sponsor.

NCT06831955 — LifEStyle Intervention to Enhance Efficacy of Neoadjuvant Therapy in Patients With Triple Negative Breast Cancer · Phase 2 · recruiting
NCT07356505 — Efficacy and Safety of Micra AV2 Transcatheter Pacing System · NA · recruiting
NCT07286968 — Gastro-Intestinal Digestion and Physiology After Bariatric Surgery · recruiting
NCT06962137 — Phase II RAINSPOT: Zolbetuximab-Paclitaxel-Ramucirumab for CLDN18.2 Positive Gastro-esophageal Cancer · Phase 2 · recruiting
NCT07270536 — Accelerated Pacing and Cardiac Filling Pressures During Exercise in Patients With Heart Failure With Preserved Ejection · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03408691 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Universitaire Ziekenhuizen KU Leuven
Last refreshed: 4 June 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03408691.

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