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NCT03408457
Influence of Perioperative Fluid Balance on Serum Concentrations of Antibiotics and Surgical Site Infections
trial testing Blood sampling after antibiotic administration in Antibiotic in 130 participants. Completed in 14 May 2019.
4 April 2019
Quick facts
| Lead sponsor | Johannes Gutenberg University Mainz |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 130 |
| Start date | 14 March 2018 |
| Primary completion | 4 April 2019 |
| Estimated completion | 14 May 2019 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Blood sampling after antibiotic administration
Conditions studied
- Antibiotic — all drugs for Antibiotic →
- Anti-Bacterial Agents — all drugs for Anti-Bacterial Agents →
- Surgical Wound Infection — all drugs for Surgical Wound Infection →
Sponsor
Johannes Gutenberg University Mainz
Who can join
18 and older, any sex, with Antibiotic or Anti-Bacterial Agents. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study evaluates antibiotic serum concentrations in correlation with perioperative fluid balance. Patients will be recruited in rectum and esophageal surgery (representative for low blood loss and restrictive fluid management) and in liver surgery (representative for high blood loss and liberal fluid management). The hypothesis is that high blood loss and liberal fluid management dilute antibiotic serum concentrations thereby potentially increasing surgical site infections.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03408457
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03408457 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Johannes Gutenberg University Mainz
- Last refreshed: 30 May 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03408457.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing