Who is sponsoring NCT03405909?

NCT03405909 is sponsored by University Hospital Erlangen.

What drugs are being tested in NCT03405909?

Interventions in NCT03405909: contrast enhanced ultrasound (CEUS), MRI, Histology.

What condition does NCT03405909 study?

NCT03405909 studies Hepatocellular Carcinoma, Cholangiocarcinoma, Intrahepatic, Liver Cirrhosis, Liver Cancer, Liver Neoplasms, Liver Diseases.

Is NCT03405909 still recruiting?

NCT03405909 is currently completed. Last updated 2 March 2021.

Last reviewed 2021-03-02 · How we verify

NCT03405909: ESCULAP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Standardized CEUS Algorithms for Diagnosis of HCC - Prospective German Multicenter Study

Completed Last updated 2 March 2021

What this trial tests

trial testing contrast enhanced ultrasound (CEUS) in Hepatocellular Carcinoma in 517 participants. Completed in 6 April 2019.

Timeline

21 April 2018

Primary endpoint
6 April 2019

6 April 2019

Quick facts

Lead sponsor	University Hospital Erlangen
Status	Completed
Study type	OBSERVATIONAL
Enrollment	517
Start date	21 April 2018
Primary completion	6 April 2019
Estimated completion	6 April 2019
Sites	1 location across Germany

Drugs / interventions tested

contrast enhanced ultrasound (CEUS) — full drug profile →
MRI — full drug profile →
Histology — full drug profile →

Conditions studied

Hepatocellular Carcinoma — all drugs for Hepatocellular Carcinoma →
Cholangiocarcinoma, Intrahepatic — all drugs for Cholangiocarcinoma, Intrahepatic →
Liver Cirrhosis — all drugs for Liver Cirrhosis →
Liver Cancer — all drugs for Liver Cancer →

Sponsor

University Hospital Erlangen

Who can join

18 and older, any sex, with Hepatocellular Carcinoma or Cholangiocarcinoma, Intrahepatic. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Aim of this prospective national multicenter study is to improve standardization of contrast-enhanced ultrasound (CEUS) in the non-invasive diagnosis of hepatocellular carcinoma (HCC) in high-risk patients. The study is funded by the German Society for Ultrasound in Medicine (DEGUM).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Real-life assessment of standardized contrast-enhanced ultrasound (CEUS) and CEUS algorithms (CEUS LI-RADS®/ESCULAP) in hepatic nodules in cirrhotic patients-a prospective multicenter study.
Strobel D, Jung EM, Ziesch M, Praktiknjo M, et al · · 2021 · cited 32× · PMID 33855588 · DOI 10.1007/s00330-021-07872-3

Verify or expand the search:

Other recruiting trials for Hepatocellular Carcinoma

Currently open trials in the same condition.

NCT06902246 — Regorafenib and Yttrium-90 Radioembolization for Unresectable Hepatocellular Carcinoma · Phase 2 · recruiting
NCT05842174 — Targeting Ischemia-Induced Autophagy Dependence in Hepatocellular Carcinoma · Phase 1, PHASE2 · recruiting
NCT07417397 — Adjuvant TACE in HCC With High-risk Recurrence Factors · Phase 3 · recruiting
NCT07317414 — β-alanine in the Treatment of Advanced Hepatocellular Carcinoma · Phase 2 · recruiting
NCT07148050 — Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimer · Phase 1 · recruiting

Other University Hospital Erlangen trials

Trials by the same sponsor.

NCT07347535 — Non-invasive MSOT Examination of Muscle Oxygenation in Athletes and PAD Patients · not yet recruiting
NCT06994260 — Diagnostic Imaging of Vascular Malformations Using MSOT and ULM · not yet recruiting
NCT06966297 — MSOT_PI Analysis of Revascularization Procedure Using Optoacoustic Imaging · completed
NCT05773547 — Investigation of the Learning Effect in the Measurement of Circulation in Calf Muscle Using MSOT · unknown
NCT05110677 — Pilot Study of Topographic Imaging of the Calf Muscle in Patients With PAD Using 3D Reconstruction of MSOT Images · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03405909 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital Erlangen
Last refreshed: 2 March 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03405909.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing