NCT03405675: SLAS

Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)

Status unknown Last updated 14 March 2019

What this trial tests

trial testing SLAS 1 in Cognitive Changes Due to Organic Disorder (Finding) in 6,183 participants. Status unknown.

Timeline

1 July 2003

Primary endpoint
31 December 2020

31 December 2020

Quick facts

Lead sponsor	National University of Singapore
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	6,183
Start date	1 July 2003
Primary completion	31 December 2020
Estimated completion	31 December 2020
Sites	1 location across Singapore

Drugs / interventions tested

• SLAS 1
• SLAS 2

Conditions studied

• Cognitive Changes Due to Organic Disorder (Finding) — all drugs for Cognitive Changes Due to Organic Disorder (Finding) →
• Dementia — all drugs for Dementia →
• Mild Cognitive Impairment — all drugs for Mild Cognitive Impairment →
• Frailty — all drugs for Frailty →

Sponsor

National University of Singapore

Who can join

55 and older, any sex, with Cognitive Changes Due to Organic Disorder (Finding) or Dementia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The Gerontology Research Programme (GRP) in the National University Singapore's Department of Psychological Medicine, was formed to coordinate and facilitate the conduct of multi-disciplinary research on in a wide range of research on ageing and health. The establishment of the Singapore Longitudinal Aging Cohort will provide a large community-based cohort of elderly subjects for observational studies with useful clinical applications. Research synergy is achieved in terms of pooling multi-disciplinary expertise, and combining genetic, biological, environmental, behavioural, social, clinical, and health services approaches to gerontological research.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

1. Singapore multidisciplinary consensus recommendations on muscle health in older adults: assessment and multimodal targeted intervention across the continuum of care.
   Chew STH, Kayambu G, Lew CCH, Ng TP, et al · · 2021 · cited 19× · PMID 34001023 · DOI 10.1186/s12877-021-02240-8
2. Functional mobility decline and incident mild cognitive impairment and early dementia in community-dwelling older adults: the Singapore Longitudinal Ageing Study.
   Ng TP, Lee TS, Lim WS, Chong MS, et al · · 2022 · cited 17× · PMID 36074716 · DOI 10.1093/ageing/afac182
3. Friendly visiting by a volunteer for reducing loneliness or social isolation in older adults: A systematic review.
   Laermans J, Scheers H, Vandekerckhove P, De Buck E. · · 2023 · cited 10× · PMID 38034902 · DOI 10.1002/cl2.1359
4. Curcumin-rich curry consumption and life expectancy: Singapore longitudinal ageing study.
   Ng TP, Nyunt SZ, Gao Q, Gwee X, et al · · 2024 · cited 7× · PMID 37306893 · DOI 10.1007/s11357-023-00842-1
5. Dairy and fish consumption and the risk of mild cognitive impairment and dementia
   Chua DQL, Gwee X, Gao Q, Nyunt MSZ, et al · · 2020 · cited 1× · DOI 10.21203/rs.3.rs-36469/v1
6. Differential metabolomic prediction of outcomes in HFpEF and HFrEF: a prospective international multi-ethnic cohort study.
   Wu LH, Pakkiri LS, Tromp J, Lim PL, et al · · 2026 · PMID 42035244 · DOI 10.1093/cvr/cvag090